NDLI: Interferon-gamma acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease

Content Provider	PubMed Central
Author	Mitchell, Charlotte Provost, Karin Niu, Naiqian Homer, Robert Cohn, Lauren
Abstract	Inhibiting allergic airway inflammation is the goal of therapy in persistent asthma. Administration of medication via the airways delivers drug directly to the site of inflammation and avoids systemic side effects, but often fails to modulate systemic features of asthma. We have shown that Th1 cells, through production of IFN-γ, inhibit many Th2-induced effector functions that promote disease. Using a newly generated mouse that expresses IFN-γR only on airway epithelial cells, we show that the airway epithelium controls a range of pathological responses in asthma. IFN-γ acting only through the airway epithelium inhibits mucus, chitinases and eosinophilia, independent of Th2 cell activation. IFN-γ signaling through the airway epithelium inhibits eosinophil generation in the bone marrow, indicating that signals on the airway mucosal surface can regulate distant functions to inhibit disease. IFN-γ actions through the airway epithelium will limit airway obstruction and inflammation and may be therapeutic in refractory asthma.
Related Links	http://dx.doi.org/10.4049/jimmunol.1100436
Ending Page	3820
Page Count	6
Starting Page	3815
File Format	PDF
ISSN	00221767
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	7
Volume Number	187
Language	English
Publisher Date	2011-10-01
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

γδ T cells contribute to the systemic immunoglobulin E response and local B-cell reactivity in allergic eosinophilic airway inflammation

Systemic and local interferon-gamma production following Mycobacterium ulcerans infection

Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis

Dual systemic allergic rhinitis and local allergic rhinitis

Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice 1

STAT6 Expression in Multiple Cell Types Mediates the Cooperative Development of Allergic Airway Disease

Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma 1

Regulation of Proteinase Activated Receptor-2 on airway epithelium

Systemic and local interferon-gamma production following Mycobacterium ulcerans infection.

Interferon-gamma acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease

Similar Documents

γδ T cells contribute to the systemic immunoglobulin E response and local B-cell reactivity in allergic eosinophilic airway inflammation

Systemic and local interferon-gamma production following Mycobacterium ulcerans infection

Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis

Dual systemic allergic rhinitis and local allergic rhinitis

Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice 1

STAT6 Expression in Multiple Cell Types Mediates the Cooperative Development of Allergic Airway Disease

Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma 1

Regulation of Proteinase Activated Receptor-2 on airway epithelium

Systemic and local interferon-gamma production following Mycobacterium ulcerans infection.

Interferon-gamma acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease