NDLI: Clock Genes Show Circadian Rhythms in Salivary Glands

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Clock Genes Show Circadian Rhythms in Salivary Glands

Content Provider	PubMed Central
Author	Zheng, L. Seon, Y. J. Mchugh, J. Papagerakis, S. Papagerakis, P.
Copyright Year	2012
Abstract	Circadian rhythms are endogenous self-sustained oscillations with 24-hour periods that regulate diverse physiological and metabolic processes through complex gene regulation by “clock” transcription factors. The oral cavity is bathed by saliva, and its amount and content are modified within regular daily intervals. The clock mechanisms that control salivary production remain unclear. Our objective was to evaluate the expression and periodicity of clock genes in salivary glands. Real-time quantitative RT-PCR, in situ hybridization, and immunohistochemistry were performed to show circadian mRNA and protein expression and localization of key clock genes (Bmal1, Clock, Per1, and Per2), ion and aqua channel genes (Ae2a, Car2, and Aqp5), and salivary gland markers. Clock gene mRNAs and clock proteins were found differentially expressed in the serous acini and duct cells of all major salivary glands. The expression levels of clock genes and Aqp5 showed regular oscillatory patterns under both light/dark and complete-dark conditions. Bmla1 overexpression resulted in increased Aqp5 expression levels. Analysis of our data suggests that salivary glands have a peripheral clock mechanism that functions both in normal light/dark conditions and in the absence of light. This finding may increase our understanding of the control mechanisms of salivary content and flow.
Related Links	http://dx.doi.org/10.1177/0022034512451450
Ending Page	788
Page Count	6
Starting Page	783
File Format	PDF
ISSN	00220345
e-ISSN	15440591
Journal	Journal of Dental Research
Issue Number	8
Volume Number	91
Language	English
Publisher	SAGE Publications
Publisher Date	2012-08-01
Access Restriction	Open
Rights Holder	SAGE Publications
Subject Keyword	Dentistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Dentistry

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