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Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver
| Content Provider | MDPI |
|---|---|
| Author | Koritala, Bala S. C. Lee, Yin Yeng Bhadri, Shweta S. Gaspar, Laetitia S. Stanforth, Corinne Wu, Gang Ruben, Marc D. Francey, Lauren J. Smith, David F. |
| Copyright Year | 2021 |
| Description | At least one-third of adults in the United States experience intermittent hypoxia (IH) due to health or living conditions. The majority of these adults suffer with sleep breathing conditions and associated circadian rhythm disorders. The impact of IH on the circadian clock is not well characterized. In the current study, we used an IH mouse model to understand the impact of IH on the circadian gene expression of the canonical clock genes in the central (the brain) and peripheral (the liver) tissues. Gene expression was measured using a Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). CircaCompare was used to evaluate the differential rhythmicity between normoxia and IH. Our observations suggested that the circadian clock in the liver was less sensitive to IH compared to the circadian clock in the brain. |
| Starting Page | 1627 |
| e-ISSN | 20734425 |
| DOI | 10.3390/genes12101627 |
| Journal | Genes |
| Issue Number | 10 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-10-16 |
| Access Restriction | Open |
| Subject Keyword | Genes Intermittent Hypoxia Circadian Rhythms Canonical Clock Genes |
| Content Type | Text |
| Resource Type | Article |
