NDLI: Differential Spatial Expression and Subcellular Localization of CtBP Family Members in Rodent Brain

Content Provider	PubMed Central
Author	Hübler, Diana Rankovic, Marija Richter, Karin Lazarevic, Vesna Altrock, Wilko D. Fischer, Klaus-dieter Gundelfinger, Eckart D. Anna, Fejtova
Editor	Malmierca, Manuel S.
Copyright Year	2012
Abstract	C-terminal binding proteins (CtBPs) are well-characterized nuclear transcriptional co-regulators. In addition, cytoplasmic functions were discovered for these ubiquitously expressed proteins. These include the involvement of the isoform CtBP1-S/BARS50 in cellular membrane-trafficking processes and a role of the isoform RIBEYE as molecular scaffolds in ribbons, the presynaptic specializations of sensory synapses. CtBPs were suggested to regulate neuronal differentiation and they were implied in the control of gene expression during epileptogenesis. However, the expression patterns of CtBP family members in specific brain areas and their subcellular localizations in neurons in situ are largely unknown. Here, we performed comprehensive assessment of the expression of CtBP1 and CtBP2 in mouse brain at the microscopic and the ultra-structural levels using specific antibodies. We quantified and compared expression levels of both CtBPs in biochemically isolated brain fractions containing cellular nuclei or synaptic compartment. Our study demonstrates differential regional and subcellular expression patterns for the two CtBP family members in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions. Finally, we propose a mechanism of differential synapto-nuclear targeting of its splice variants CtBP2-S and CtBP2-L in neurons.
Related Links	http://dx.doi.org/10.1371/journal.pone.0039710
Starting Page	39710
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	6
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-06-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Expression Pattern and Subcellular Localization of the Ovate Protein Family in Rice

Activation-Induced Cytidine Deaminase Alters the Subcellular Localization of Tet Family Proteins

Corticolimbic Expression of TRPC4 and TRPC5 Channels in the Rodent Brain

MIF Family Members Cooperatively Inhibit p53 Expression and Activity

Expression and Subcellular Localization of Mammalian Formin Fhod3 in the Embryonic and Adult Heart

Differential Expression of Three Members of the Multidomain Adhesion CCp Family in Babesia bigemina, Babesia bovis and Theileria equi

Osmotic Stress Changes the Expression and Subcellular Localization of the Batten Disease Protein CLN3

Expression Patterns and Subcellular Localization of Carbonic Anhydrases Are Developmentally Regulated during Tooth Formation

MicroRNA-99 Family Members Suppress Homeobox A1 Expression in Epithelial Cells

Differential Spatial Expression and Subcellular Localization of CtBP Family Members in Rodent Brain

Similar Documents

Expression Pattern and Subcellular Localization of the Ovate Protein Family in Rice

Activation-Induced Cytidine Deaminase Alters the Subcellular Localization of Tet Family Proteins

Corticolimbic Expression of TRPC4 and TRPC5 Channels in the Rodent Brain

MIF Family Members Cooperatively Inhibit p53 Expression and Activity

Expression and Subcellular Localization of Mammalian Formin Fhod3 in the Embryonic and Adult Heart

Differential Expression of Three Members of the Multidomain Adhesion CCp Family in Babesia bigemina, Babesia bovis and Theileria equi

Osmotic Stress Changes the Expression and Subcellular Localization of the Batten Disease Protein CLN3

Expression Patterns and Subcellular Localization of Carbonic Anhydrases Are Developmentally Regulated during Tooth Formation

MicroRNA-99 Family Members Suppress Homeobox A1 Expression in Epithelial Cells

Differential Spatial Expression and Subcellular Localization of CtBP Family Members in Rodent Brain