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| Content Provider | PubMed Central |
|---|---|
| Author | Anderson, Philip D. Nelson, Vicki R. Tesar, Paul J. Nadeau, Joseph H. |
| Abstract | Despite strong heritability, little is known about the genetic control of susceptibility to testicular germ cell tumors (TGCTs) in humans or mice. Although the mouse model of spontaneous TGCTs has been extensively studied, conventional linkage analysis has failed to locate the factors that control both teratocarcinogenesis in the susceptible 129 family of inbred strains. As an alternative approach, we used both chromosome substitution strains (CSSs) to identify individual chromosomes that harbor susceptibility genes, and a panel of congenic strains derived from a selected CSS to determine the number and location of susceptibility variants on the substituted chromosome. We showed that 129-Chr 18MOLF males are resistant to spontaneous TGCTs and that at least four genetic variants control susceptibility in males with this substituted chromosome. In addition, early embryonic cells from this strain fail to establish embryonic stem (ES) cell lines as efficiently as those from the parental 129/Sv strain. For the first time, 129-derived genetic variants that control TGCT susceptibility and fundamental aspects of ES cell biology have been localized in a genetic context where the genes can be identified and functionally characterized. |
| Related Links | http://dx.doi.org/10.1158/0008-5472.can-09-3342 |
| Ending Page | 9117 |
| Page Count | 6 |
| Starting Page | 9112 |
| File Format | |
| ISSN | 00085472 |
| e-ISSN | 15387445 |
| Journal | Cancer Research |
| Issue Number | 23 |
| Volume Number | 69 |
| Language | English |
| Publisher Date | 2009-12-01 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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