NDLI: Recognition and Killing of Brain Tumor Stem-Like Initiating Cells by CD8+ Cytolytic T Cells

Content Provider	PubMed Central
Author	Brown, Christine E. Starr, Renate Martinez, Catalina Aguilar, Brenda Massimo, D'apuzzo Todorov, Ivan Shih, Chu-chih Badie, Behnam Hudecek, Michael Riddell, Stanley R. Jensen, Michael C.
Abstract	Solid tumors contain a subset of stem-like cells that are resistant to the cytotoxic effects of chemo/radio-therapy, but their susceptibility to cytolytic T lymphocyte (CTL) effector mechanisms has not been well characterized. Using a panel of early-passage human brain tumor stem cell (BTSC) lines derived from high-grade gliomas, we demonstrate that BTSCs are subject to immunologic recognition and elimination by CD8+ CTLs. Compared to serum differentiated CD133low tumor cells and established glioma cell lines, BTSCs are equivalent with respect to expression levels of HLA class I and ICAM-1, similar in their ability to trigger degranulation and cytokine synthesis by antigen-specific CTLs, and equally susceptible to perforin-dependent CTL mediated cytolysis. BTSCs are also competent in the processing and presentation of antigens as evidenced by the killing of these cells by CTL when antigen is endogenously expressed. Moreover, we show that CTLs can eliminate all BTSCs with tumor initiating activity in an antigen specific manner in vivo. Current models predict that curative therapies for many cancers will require the elimination of the stem/initiating population, and these studies lay the foundation for developing immunotherapeutic approaches to eradicate this tumor population.
Related Links	http://dx.doi.org/10.1158/0008-5472.can-09-2687
Ending Page	8893
Page Count	8
Starting Page	8886
File Format	PDF
ISSN	00085472
e-ISSN	15387445
Journal	Cancer research
Issue Number	23
Volume Number	69
Language	English
Publisher Date	2009-12-01
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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