NDLI: Arterial stiffness, central hemodynamics, and cardiovascular risk in hypertension

Content Provider	PubMed Central
Author	Palatini, Paolo Casiglia, Edoardo Gąsowski, Jerzy Głuszek, Jerzy Jankowski, Piotr Narkiewicz, Krzysztof Francesca, Saladini Stolarz-skrzypek, Katarzyna Tikhonoff, Valérie Bortel, Luc Van Wojciechowska, Wiktoria Kalina, Kawecka-jaszcz
Copyright Year	2011
Abstract	This review summarizes several scientific contributions at the recent Satellite Symposium of the European Society of Hypertension, held in Milan, Italy. Arterial stiffening and its hemodynamic consequences can be easily and reliably measured using a range of noninvasive techniques. However, like blood pressure (BP) measurements, arterial stiffness should be measured carefully under standardized patient conditions. Carotid-femoral pulse wave velocity has been proposed as the gold standard for arterial stiffness measurement and is a well recognized predictor of adverse cardiovascular outcome. Systolic BP and pulse pressure in the ascending aorta may be lower than pressures measured in the upper limb, especially in young individuals. A number of studies suggest closer correlation of end-organ damage with central BP than with peripheral BP, and central BP may provide additional prognostic information regarding cardiovascular risk. Moreover, BP-lowering drugs can have differential effects on central aortic pressures and hemodynamics compared with brachial BP. This may explain the greater beneficial effect provided by newer antihypertensive drugs beyond peripheral BP reduction. Although many methodological problems still hinder the wide clinical application of parameters of arterial stiffness, these will likely contribute to cardiovascular assessment and management in future clinical practice. Each of the abovementioned parameters reflects a different characteristic of the atherosclerotic process, involving functional and/or morphological changes in the vessel wall. Therefore, acquiring simultaneous measurements of different parameters of vascular function and structure could theoretically enhance the power to improve risk stratification. Continuous technological effort is necessary to refine our methods of investigation in order to detect early arterial abnormalities. Arterial stiffness and its consequences represent the great challenge of the twenty-first century for affluent countries, and “de-stiffening” will be the goal of the next decades.
Related Links	http://dx.doi.org/10.2147/vhrm.s25270
Ending Page	739
Starting Page	725
File Format	PDF
ISSN	11782048
e-ISSN	11782048
Journal	Vascular Health and Risk Management
Volume Number	7
Language	English
Publisher	Dove Medical Press
Publisher Date	2011-12-01
Access Restriction	Open
Rights Holder	Dove Medical Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article

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