NDLI: Selective ablation of retinoid X receptor α in hepatocytesimpairs their lifespan and regenerative capacity

Content Provider	PubMed Central
Author	Imai, Takeshi Jiang, Ming Kastner, Philippe Chambon, Pierre Metzger, Daniel
Copyright Year	2001
Abstract	Retinoid X receptors (RXRs) are involved in a number of signalingpathways as heterodimeric partners of numerous nuclear receptors.Hepatocytes express high levels of the RXRα isotype, as well asseveral of its putative heterodimeric partners. Germ-line disruption(knockout) of RXRα has been shown to be lethal inutero, thus precluding analysis of its function at later lifestages. Hepatocyte-specific disruption of RXRα during liverorganogenesis has recently revealed that the presence of hepatocytes isnot mandatory for the mouse, at least under normal mouse facilityconditions, even though a number of metabolic events are impaired[Wan, Y.-J., et al. (2000) Mol. Cell.Biol. 20, 4436–4444]. However, it is unknown whether RXRαplays a role in the control of hepatocyte proliferation and lifespan.Here, we report a detailed analysis of the liver of mice in whichRXRα was selectively ablated in adult hepatocytes by using thetamoxifen-inducible chimeric Cre recombinase system. Our results showthat the lifespan of adult hepatocytes lacking RXRα is shorter thanthat of their wild-type counterparts, whereas proliferative hepatocytesof regenerating liver exhibit an even shorter lifespan. These lifespanshortenings are accompanied by increased polyploidy andmultinuclearity. We conclude that RXRα plays importantcell-autonomous function(s) in the mechanism(s) involved in thelifespan of hepatocytes and liver regeneration.
Related Links	http://dx.doi.org/10.1073/pnas.071056098
Ending Page	4586
Page Count	6
Starting Page	4581
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-04-10
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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