NDLI: Effect of Novel Marine Nutraceuticals on IL-1 α -Mediated TNF- α Release from UVB-Irradiated Human Melanocyte-Derived Cells

Content Provider	PubMed Central
Author	Muthusamy, Visalini Hodges, Lynn D. Macrides, Theodore A. Boyle, Glen M. Piva, Terrence J.
Copyright Year	2011
Abstract	UV-induced inflammation and reactive oxygen species formation are involved in the development of melanoma. Natural products like 5 β -scymnol and CO2-supercritical fluid extract (CO2-SFE) of mussel oil contain anti-inflammatory and antioxidant properties that may aid in reducing the deleterious effects of UV radiation. Therefore, their effect on the release of the proinflammatory cytokine, tumour necrosis factor- α (TNF- α ), from UVB-irradiated human melanocytic cells was examined. Human epidermal melanocytes (HEM) and MM96L melanoma cells were exposed to UVB radiation and IL-1 α . Cell viability and TNF- α levels were determined 24 hours after-irradiation while p38 mitogen-activated protein kinase (MAPK) activation was observed at 15 min after-irradiation. When α -tocopherol, CO2-SFE mussel oil, and 5β-scymnol were added to the UVB-irradiated HEM cells treated with IL-1 α , TNF- α levels fell by 53%, 65%, and 76%, respectively, while no inhibition was evident in MM96L cells. This effect was not due to inhibition of the intracellular p38 MAPK signalling pathway. These compounds may be useful in preventing inflammation-induced damage to normal melanocytes.
Related Links	http://dx.doi.org/10.1155/2011/728645
Starting Page	728645
File Format	PDF
ISSN	19420900
e-ISSN	19420994
Journal	Oxidative Medicine and Cellular Longevity
Volume Number	2011
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Cell Biology Biochemistry Ageing Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Aging Medicine Biochemistry

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