NDLI: Related pituitary cell lineages develop into interdigitated 3D cell networks

Content Provider	PubMed Central
Author	Budry, Lionel Lafont, Chrystel Taoufik, El Yandouzi Chauvet, Norbert Conéjero, Geneviève Drouin, Jacques Mollard, Patrice
Abstract	The pituitary gland has long been considered to be a random patchwork of hormone-producing cells. By using pituitary-scale tridimensional imaging for two of the least abundant cell lineages, the corticotropes and gonadotropes, we have now uncovered highly organized and interdigitated cell networks that reflect homotypic and heterotypic interactions between cells. Although newly differentiated corticotrope cells appear on the ventral surface of the gland, they rapidly form homotypic strands of cells that extend from the lateral tips of the anterior pituitary along its ventral surface and into the medial gland. As the corticotrope network is established away from the microvasculature, cell morphology changes from rounded, to polygonal, and finally to cells with long cytoplasmic processes or cytonemes that connect corticotropes to the perivascular space. Gonadotropes differentiate later and are positioned in close proximity to corticotropes and capillaries. Blockade of corticotrope terminal differentiation produced by knockout of the gene encoding the transcription factor Tpit results in smaller gonadotropes within an expanded cell network, particularly in the lateral gland. Thus, pituitary-scale tridimensional imaging reveals highly structured cell networks of unique topology for each pituitary lineage. The sequential development of interdigitated cell networks during organogenesis indicate that extensive cell:cell interactions lead to a highly ordered cell positioning rather than random patchwork.
Related Links	http://dx.doi.org/10.1073/pnas.1105929108
Ending Page	12520
Page Count	6
Starting Page	12515
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	30
Volume Number	108
Language	English
Publisher	National Academy of Sciences
Publisher Date	2011-07-26
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Related pituitary cell lineages develop into interdigitated 3D cell networks.

Recombination between elongation factor 1α genes from distantly related archaeal lineages

Distribution of histone H3.3 in hematopoietic cell lineages

Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry

Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi

Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation

Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages

Stellate Cell Networks in the Teleost Pituitary

Regulating synthetic gene networks in 3D materials

Related pituitary cell lineages develop into interdigitated 3D cell networks

Similar Documents

Related pituitary cell lineages develop into interdigitated 3D cell networks.

Recombination between elongation factor 1α genes from distantly related archaeal lineages

Distribution of histone H3.3 in hematopoietic cell lineages

Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry

Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi

Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation

Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages

Stellate Cell Networks in the Teleost Pituitary

Regulating synthetic gene networks in 3D materials

Related pituitary cell lineages develop into interdigitated 3D cell networks