NDLI: Analysis of the Potential Topical Anti-Inflammatory Activity of Averrhoa carambola L. in Mice

Content Provider	PubMed Central
Author	Cabrini, Daniela Almeida Moresco, Henrique Hunger Imazu, Priscila Silva, Cíntia Delai Da Fernandes, Pietrovski Evelise Mendes, Daniel Augusto Gasparin Bueno Prudente, Arthur Da Silveira Geraldo, Pizzolatti Moacir Costa, Brighente Inês Maria Otuki, Michel Fleith
Copyright Year	2011
Abstract	Inflammatory skin disorders, such as psoriasis and atopic dermatitis, are very common in the population; however, the treatments currently available are not well tolerated and are often ineffective. Averrhoa carambola L. (Oxalidaceae) is an Asian tree that has been used in traditional folk medicine in the treatment of several skin disorders. The present study evaluates the topical anti-inflammatory effects of the crude ethanolic extract of A. carambola leaves, its hexane, ethyl acetate, and butanol fractions and two isolated flavonoids on skin inflammation. Anti-inflammatory activity was measured using a croton oil-induced ear edema model of inflammation in mice. Topically applied ethanolic extract reduced edema in a dose-dependent manner, resulting in a maximum inhibition of 73 ± 3% and an ID50 value of 0.05 (range: 0.02–0.13) mg/ear. Myeloperoxidase (MPO) activity was also inhibited by the extract, resulting in a maximum inhibition of 60 ± 6% (0.6 mg/ear). All of the fractions tested caused inhibition of edema formation and of MPO activity. Treatment with the ethyl acetate fraction was the most effective, resulting in inhibition levels of 75 ± 5 and 54 ± 8% for edema formation and MPO activity, respectively. However, treatment of mice with isolated compounds [apigenin-6-C- β -l-fucopyranoside and apigenin-6-C-(2 ″ -O- α -l-rhamnopyranosyl)- β -l-fucopyranoside] did not yield successful results. Apigenin-6-C-(2 ″ -O- α -l-rhamnopyranosyl)- β -l-fucopyranoside caused only a mild reduction in edema formation (28 ± 11%). Taken together, these preliminary results support the popular use of A. carambola as an anti-inflammatory agent and open up new possibilities for its use in skin disorders.
Related Links	http://dx.doi.org/10.1093/ecam/neq026
Starting Page	908059
File Format	PDF
ISSN	1741427X
e-ISSN	17414288
Journal	Evidence-based Complementary and Alternative Medicine : eCAM
Volume Number	2011
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Complementary and alternative medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Analysis of the Potential Topical Anti-Inflammatory Activity of Averrhoa carambola L. in Mice

Anti-Obesity Evaluation of Averrhoa carambola L. Leaves and Assessment of Its Polyphenols as Potential α-Glucosidase Inhibitors

Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography–mass spectrometry

Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825)

Isocoumarins and Dihydroisocoumarins From the Endophytic Fungus Biscogniauxia capnodes Isolated From the Fruits of Averrhoa carambola

Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark

Protective Effect of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn. Extracts against Ultraviolet B-Induced Damage in Human Keratinocytes

Analgesic and Anti-Inflammatory Activities of Methanol Extract of Ficus pumila L. in Mice

Analysis of the Potential Topical Anti-Inflammatory Activity of Averrhoa carambola L. in Mice

Similar Documents

Analysis of the Potential Topical Anti-Inflammatory Activity of Averrhoa carambola L. in Mice

Anti-Obesity Evaluation of Averrhoa carambola L. Leaves and Assessment of Its Polyphenols as Potential α-Glucosidase Inhibitors

Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography–mass spectrometry

Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825)

Isocoumarins and Dihydroisocoumarins From the Endophytic Fungus Biscogniauxia capnodes Isolated From the Fruits of Averrhoa carambola

Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark

Protective Effect of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn. Extracts against Ultraviolet B-Induced Damage in Human Keratinocytes

Analgesic and Anti-Inflammatory Activities of Methanol Extract of Ficus pumila L. in Mice

Analysis of the Potential Topical Anti-Inflammatory Activity of Averrhoa carambola L. in Mice