NDLI: Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation

Content Provider	PubMed Central
Author	Harahap, Indra Sari Kusuma Sasaki, Naoko Yusoff, Surini Lee, Myeong Jin Morikawa, Satoru Nishimura, Noriyuki Sasaki, Tomohiro Usuki, Seiichiro Hirai, Midori Ohta, Mika Takaoka, Yutaka Nishimoto, Takashi Nishio, Hisahide Gunadi
Copyright Year	2011
Abstract	Licorice ingestion, as well as mutations in the HSD11B2 gene, inhibits 11 β -hydroxysteroid dehydrogenase type 2 (11 β HSD2) enzyme activity, causing the syndrome of apparent mineral corticoid excess (AME). However, the combined effect of licorice ingestion and an HSD11B2 mutation has never been reported, until now. In this study, we demonstrated that licorice ingestion can produce overt hypertension in an individual without medical history of hypertension who is heterozygous for wild-type and mutant HSD11B2 genes. Our patient was a 51-year-old female with serious hypertension who had been taking herbal medicine containing licorice for more than one year. She was clinically diagnosed as having licorice intoxication, because she did not present with hypertension after ceasing the herbal medicine. Molecular analysis showed that she carried a missense mutation, c.40C>T, in HSD11B2. In conclusion, licorice ingestion is an environmental risk factor for hypertension or AME state in patients with a mutation in HSD11B2. Carrying a mutation in HSD11B2 is, conversely, a genetic risk factor for licorice-induced hypertension or AME state. Herbal medicine containing licorice may, therefore, be contraindicated in patients with an HSD11B2 mutation.
Related Links	http://dx.doi.org/10.1093/ecam/nep211
Starting Page	646540
File Format	PDF
ISSN	1741427X
e-ISSN	17414288
Journal	Evidence-based Complementary and Alternative Medicine : eCAM
Volume Number	2011
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Complementary and alternative medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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