NDLI: The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata

Content Provider	PubMed Central
Author	Xiao, Liang Liu, Sihua He, Qian Wang, Qianqian Ye, Xuting Liu, Guoyan Nie, Fei Zhao, Jie Zhang, Liming
Copyright Year	2011
Abstract	To investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median lethal dose (LD50) of TOE was 4.25 mg/kg, and the acute toxicity involved both heart- and nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO2, HCO3 −, HCO3std, TCO2, BEecf and BE (B), decreased significantly. PO2 showed a slight increase, while SO2c (%) had no change at any time. Na+ and Ca2+ decreased, but K+ increased. Biochemical indexes, including LDH, CK, CK-MB, ALT, AST and sCr, significantly increased. Other biochemical indexes, including BUN and hemodiastase, remained normal. Lactic acid significantly increased, while glucose, Hct% and THbc showed slight temporary increases and then returned to normal. These results on the acute toxicity and hematological changes should improve our understanding of the in vivo pathophysiological effects of TOE from C. capillata and indicate that it may also have neurotoxicity, liver toxicity and muscular toxicity in addition to hemolytic and cardiovascular toxicities, but no kidney or pancreatic toxicity.
Related Links	http://dx.doi.org/10.3390/md9040526
Ending Page	534
Page Count	9
Starting Page	526
File Format	PDF
ISSN	16603397
e-ISSN	16603397
Journal	Marine Drugs
Issue Number	4
Volume Number	9
Language	English
Publisher	Molecular Diversity Preservation International
Publisher Date	2011-03-01
Access Restriction	Open
Rights Holder	Molecular Diversity Preservation International
Subject Keyword	Drug Discovery Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science

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The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata

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