NDLI: Intracellular Ca$^{2+}$ Overload Induced by Extracellular Ca$^{2+}$ Entry Plays an Important Role in Acute Heart Dysfunction by Tentacle Extract from the Jellyfish Cyanea capillata

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Intracellular Ca$^{2+}$ Overload Induced by Extracellular Ca$^{2+}$ Entry Plays an Important Role in Acute Heart Dysfunction by Tentacle Extract from the Jellyfish Cyanea capillata

Content Provider	Springer Nature Link
Author	Zhang, Lin He, Qian Wang, Qianqian Zhang, Bo Wang, Beilei Xu, Feng Wang, Tao Xiao, Liang Zhang, Liming
Copyright Year	2014
Abstract	The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellular Ca$^{2+}$. The heart indexes, including HR, APs, LVPs, and MMLs, were all decreased significantly by TE in both whole animal and Langendorff-perfused isolated heart model. Imbalance of cardiac oxygen supply and demand also took place. In both Ca$^{2+}$-containing and Ca$^{2+}$-free bathing solutions, TE could cause obvious cytoplasmic Ca$^{2+}$ overload in NRVMs, but the cytoplasmic Ca$^{2+}$ increased faster, Ca$^{2+}$ overload peaks arrived earlier, and the morphological changes were more severe under the extracellular Ca$^{2+}$-containing condition. L-type Ca$^{2+}$ channel blockers, as well as the inhibitor of ryanodine receptor (ryanodine), could improve the viability of NRVMs. Moreover, diltiazem significantly inhibited the acute heart dysfunction caused by TE in both Langendorff isolated heart model and whole animal. These results suggested that intracellular Ca$^{2+}$ overload induced by extracellular Ca$^{2+}$ entry plays an important role in acute heart failure by TE from the jellyfish C. capillata. Inhibition of extracellular Ca$^{2+}$ influx is a promising antagonistic alternative for heart damage by jellyfish venom.
Starting Page	260
Ending Page	274
Page Count	15
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	14
Issue Number	3
e-ISSN	15590259
Language	English
Publisher	Springer US
Publisher Date	2014-02-22
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Jellyfish Cyanea capillata Tentacle extract Acute heart dysfunction Ca$^{2+}$ overload Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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