NDLI: A novel family of retrotransposon-like elements in Xenopus laevis with a transcript inducible by two growth factors.

Content Provider	PubMed Central
Author	Greene, J. M. Otani, H. Good, P. J. Dawid, I. B.
Abstract	A cDNA clone named 1A11 was isolated in a screen for genes that are activated by both mesoderm inducing factors FGF and activin in animal explants of Xenopus laevis embryos. In undisturbed embryos, 1A11 is expressed during the gastrula stage in the entire marginal zone where mesoderm originates, and later in the somites, the tailbud, and at much lower levels in lateral mesoderm. The 1A11 sequence of 4.5 Kb has a 220 bp repeat at its ends, indicative of a retrotransposon-like structure. A long open reading frame encodes a predicted protein with only short homologies to the gag and protease regions of retroviruses and retrotransposons. Multiple copies of 1A11-related sequences were found in the Xenopus genome, constituting solo LTRs (long terminal repeats) of 1267 bp, and unique region copies (i.e., sequences internal to the repeats in the cDNA). Inverted repeats of 5 bp and apparent target site duplications of 5 bp surround the sequenced solo LTR. Thus, 1A11 is a new retrotransposon-like element in Xenopus laevis.
Starting Page	2375
File Format	PDF
ISSN	13624962
e-ISSN	13624962
Journal	Nucleic Acids Research
Issue Number	10
Volume Number	21
Language	English
Publisher Date	1993-05-25
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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A novel family of retrotransposon-like elements in Xenopus laevis with a transcript inducible by two growth factors.