NDLI: Reversal of Diabetic Nephropathy by a Ketogenic Diet

Content Provider	PubMed Central
Author	Poplawski, Michal M. Mastaitis, Jason W. Isoda, Fumiko Grosjean, Fabrizio Zheng, Feng Mobbs, Charles V.
Editor	Stadler, Krisztian
Abstract	Intensive insulin therapy and protein restriction delay the development of nephropathy in a variety of conditions, but few interventions are known to reverse nephropathy. Having recently observed that the ketone 3-beta-hydroxybutyric acid (3-OHB) reduces molecular responses to glucose, we hypothesized that a ketogenic diet, which produces prolonged elevation of 3-OHB, may reverse pathological processes caused by diabetes. To address this hypothesis, we assessed if prolonged maintenance on a ketogenic diet would reverse nephropathy produced by diabetes. In mouse models for both Type 1 (Akita) and Type 2 (db/db) diabetes, diabetic nephropathy (as indicated by albuminuria) was allowed to develop, then half the mice were switched to a ketogenic diet. After 8 weeks on the diet, mice were sacrificed to assess gene expression and histology. Diabetic nephropathy, as indicated by albumin/creatinine ratios as well as expression of stress-induced genes, was completely reversed by 2 months maintenance on a ketogenic diet. However, histological evidence of nephropathy was only partly reversed. These studies demonstrate that diabetic nephropathy can be reversed by a relatively simple dietary intervention. Whether reduced glucose metabolism mediates the protective effects of the ketogenic diet remains to be determined.
Related Links	http://dx.doi.org/10.1371/journal.pone.0018604
Starting Page	18604
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	4
Volume Number	6
Language	English
Publisher	Public Library of Science
Publisher Date	2011-04-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats

Suramin: A Potential Therapy for Diabetic Nephropathy

Predicting Diabetic Nephropathy Using a Multifactorial Genetic Model

Correction: Suramin: A Potential Therapy for Diabetic Nephropathy

Ketogenic Diet Improves Core Symptoms of Autism in BTBR Mice

Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model

Cellular Cholesterol Transport Proteins in Diabetic Nephropathy

Reduced Pain and Inflammation in Juvenile and Adult Rats Fed a Ketogenic Diet

Resveratrol Attenuates Diabetic Nephropathy via Modulating Angiogenesis

Reversal of Diabetic Nephropathy by a Ketogenic Diet

Similar Documents

An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats

Suramin: A Potential Therapy for Diabetic Nephropathy

Predicting Diabetic Nephropathy Using a Multifactorial Genetic Model

Correction: Suramin: A Potential Therapy for Diabetic Nephropathy

Ketogenic Diet Improves Core Symptoms of Autism in BTBR Mice

Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model

Cellular Cholesterol Transport Proteins in Diabetic Nephropathy

Reduced Pain and Inflammation in Juvenile and Adult Rats Fed a Ketogenic Diet

Resveratrol Attenuates Diabetic Nephropathy via Modulating Angiogenesis

Reversal of Diabetic Nephropathy by a Ketogenic Diet