NDLI: Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast

Content Provider	PubMed Central
Author	Akamatsu, Yufuko Dziadkowiec, Dorota Ikeguchi, Mitsunori Shinagawa, Hideo Iwasaki, Hiroshi
Copyright Year	2003
Abstract	Homologous recombination is an important biological process that occurs in all organisms and facilitates genome rearrangements and repair of DNA double-strand breaks. Eukaryotic Rad51 proteins (Rad51sp or Rhp51 in fission yeast) are functional and structural homologs of bacterial RecA protein, an evolutionarily conserved protein that plays a key role in homologous pairing and strand exchange between homologous DNA molecules in vitro. Here we show that the fission yeast swi5 + gene, which was originally identified as a gene required for normal mating-type switching, encodes a protein conserved among eukaryotes and is involved in a previously uncharacterized Rhp51 (Rad51sp)-dependent recombination repair pathway that does not require the Rhp55/57 (Rad55/57sp) function. Protein interactions with both Swi5 and Rhp51 were found to be mediated by a domain common to Swi2 and Sfr1 (Swi five-dependent recombination repair protein 1, a previously uncharacterized protein with sequence similarity to the C-terminal part of Swi2). Genetic epistasis analyses suggest that the Swi5–Sfr1–Rhp51 interactions function specifically in DNA recombination repair, whereas the Swi5–Swi2–Rhp51 interactions may function, together with chromodomain protein Swi6 (HP1 homolog), in mating-type switching.
Related Links	http://dx.doi.org/10.1073/pnas.2632890100
Ending Page	15775
Page Count	6
Starting Page	15770
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-12-23
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast

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Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast

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Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast