NDLI: T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool

Content Provider	PubMed Central
Author	Smith-garvin, Jennifer E. Burns, Jeremy C. Gohil, Mercy Zou, Tao Kim, Jiyeon S. Maltzman, Jonathan S. Wherry, E. John Koretzky, Gary A. Jordan, Martha S.
Abstract	SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) nucleates a signaling complex critical for T-cell receptor (TCR) signal propagation. Mutations in the tyrosines of SLP-76 result in graded defects in TCR-induced signals depending on the tyrosine(s) affected. Here we use 2 strains of genomic knock-in mice expressing tyrosine to phenylalanine mutations to examine the role of TCR signals in the differentiation of effector and memory CD8+ T cells in response to infection in vivo. Our data support a model in which altered TCR signals can determine the rate of memory versus effector cell differentiation independent of initial T-cell expansion. Furthermore, we show that TCR signals sufficient to promote CD8+ T-cell differentiation are different from those required to elicit inflammatory cytokine production.
Related Links	http://dx.doi.org/10.1182/blood-2010-06-292748
Ending Page	5559
Page Count	12
Starting Page	5548
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	25
Volume Number	116
Language	English
Publisher	American Society of Hematology
Publisher Date	2010-12-16
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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