NDLI: Impaired Set-Shifting Ability in Patients with Eating Disorders, Which Is Not Moderated by Their Catechol-O-Methyltransferase Val158Met Genotype

Content Provider	PubMed Central
Author	Kim, Youl-ri Kim, Ji Eun Kim, Mi Hyun
Copyright Year	2010
Abstract	The aim of this study was to examine the set-shifting ability in women with both anorexia nervosa (AN) and bulimia nervosa (BN) and to investigate whether it is contributed by the catechol-O-methyltransferase (COMT) Val158Met genotype. A total of 102 Korean participants-40 women with lifetime AN, 28 women with lifetime BN, and 34 healthy women of comparable age and intelligence quotient- were examined. A neuropsychological battery of tests was applied and blood samples were obtained for COMT Val158Met genotyping. Set-shifting impairments Trail Making Test (TMT, Part B) were found in patients with AN and BN, respectively. Furthermore, the eating disorders were also linked to deficits in attentional mechanisms (TMT, Part A) and motor skills (Finger Tapping Test). Finally, set-shifting and its link to eating disorders were not moderated by COMT Val158Met genotype.
Related Links	http://dx.doi.org/10.4306/pi.2010.7.4.298
Starting Page	298
File Format	PDF
ISSN	17383684
e-ISSN	19763026
Journal	Psychiatry Investigation
Issue Number	4
Volume Number	7
Language	English
Publisher	Korean Neuropsychiatric Association
Publisher Date	2010-01-01
Access Restriction	Open
Rights Holder	Korean Neuropsychiatric Association
Subject Keyword	Biological Psychiatry Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health

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Impaired Set-Shifting Ability in Patients with Eating Disorders, Which Is Not Moderated by Their Catechol-O-Methyltransferase Val158Met Genotype