NDLI: The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment

Content Provider	PubMed Central
Author	Lee, Bun-hee Kim, Yong-ku
Copyright Year	2010
Abstract	Neurotrophic factors are critical regulators of the formation and plasticity of neuronal networks. Brain-derived neurotrophic factor (BDNF) is abundant in the brain and periphery, and is found in both human serum and plasma. Animal studies have demonstrated that stress reduces BDNF expression or activity in the hippocampus and that this reduction can be prevented by treatment with antidepressant drugs. A similar change in BDNF activity occurs in the brain of patients with major depression disorder (MDD). Recently, clinical studies have indicated that serum or plasma BDNF levels are decreased in untreated MDD patients. Antidepressant treatment for at least four weeks can restore the decreased BDNF function up to the normal value. Therefore, MDD is associated with impaired neuronal plasticity. Suicidal behavior can be a consequence of severe impaired neuronal plasticity in the brain. Antidepressant treatment promotes increased BDNF activity as well as several forms of neuronal plasticity, including neurogenesis, synaptogenesis and neuronal maturation. BDNF could also play an important role in the modulation of neuronal networks. Such a neuronal plastic change can positively influence mood or recover depressed mood. These alterations of BDNF levels or neuronal plasticity in MDD patients before and after antidepressant treatment can be measured through the examination of serum or plasma BDNF concentrations. BDNF levels can therefore be useful markers for clinical response or improvement of depressive symptoms, but they are not diagnostic markers of major depression.
Related Links	http://dx.doi.org/10.4306/pi.2010.7.4.231
Starting Page	231
File Format	PDF
ISSN	17383684
e-ISSN	19763026
Journal	Psychiatry Investigation
Issue Number	4
Volume Number	7
Language	English
Publisher	Korean Neuropsychiatric Association
Publisher Date	2010-01-01
Access Restriction	Open
Rights Holder	Korean Neuropsychiatric Association
Subject Keyword	Biological Psychiatry Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health

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