NDLI: Defect of zinc transporter ZRT1 ameliorates cadmium induced lipid accumulation in Saccharomyces cerevisiae

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Metallomics Vol -9

Metallomics Vol -8

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Metallomics Vol - 8 Issue - 9

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Contents list

Alpha-synuclein: relating metals to structure, function and inhibition

LA-ICP-MS imaging in multicellular tumor spheroids – a novel tool in the preclinical development of metal-based anticancer drugs

Surface binding, localization and storage of iron in the giant kelp Macrocystis pyrifera

Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity

Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

Targeted proteomics identify metabolism-dependent interactors of yeast cytochrome c peroxidase: implications in stress response and heme trafficking

A multimodal imaging workflow to visualize metal mixtures in the human placenta and explore colocalization with biological response markers

Defect of zinc transporter ZRT1 ameliorates cadmium induced lipid accumulation in Saccharomyces cerevisiae

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Metallomics Vol - 8 Issue - 3

Metallomics Vol - 8 Issue - 2

Defect of zinc transporter ZRT1 ameliorates cadmium induced lipid accumulation in Saccharomyces cerevisiae

Content Provider	Royal Society of Chemistry (RSC)
Author	Ravi, Chidambaram Nachiappan, Vasanthi Rajakumar, Selvaraj
Copyright Year	2016
Abstract	Cadmium (Cd) is a non-essential divalent heavy metal that enters the cells by utilizing the transport pathways of the essential metals, like zinc (Zn), in Saccharomyces cerevisiae. This work focuses on Cd accumulation and its impact on deletion of Zn transporters Zrt1p and Zrt2p and lipid homeostasis. Cd exposure reduces the Zn levels in the mutant strains, and the effect was higher in zrt2Δ cells. Upon Cd exposure, the wild-type and zrt2Δ cells follow a similar pattern, but an opposite pattern was observed in zrt1Δ cells. The Cd influx and ROS levels were high in both wild-type cells and zrt2Δ cells but significantly reduced in zrt1Δ cells. Cd exposure led to accumulation of triacylglycerol and lipid droplets in wild-type cells and zrt2Δ cells but these levels were decreased in zrt1Δ cells. Hence, these studies suggest that the zrt1Δ cells provide resistance towards Cd and aid in the maintenance of lipid homeostasis in yeast cells.
Starting Page	453
Ending Page	460
Page Count	8
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	8
Issue Number	4
Journal	Metallomics
DOI	10.1039/c6mt00005c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cadmium Reactive oxygen species Mutant Homeostasis Saccharomyces Triglyceride Saccharomyces cerevisiae Heavy metals Zinc Lipid
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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Mammalian metallothioneins: properties and functions

Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis

Lipid droplets alleviate cadmium induced cytotoxicity in Saccharomyces cerevisiae

The oxidative stress of zinc deficiency

Iron homeostasis and management of oxidative stress response in bacteria

Promotion of Zn$^{2+}$ Uptake by Al$^{3+}$ in a Saccharomyces Cerevisiae Mutant that Lacks the ZRT1 Gene Encoding a High-Affinity Zn Transporter

The impact of zinc sulfate addition on the dynamic metabolic profiling of Saccharomyces cerevisiae subjected to long term acetic acid stress treatment and identification of key metabolites involved in the antioxidant effect of zinc

Bacterial iron–sulfur cluster sensors in mammalian pathogens

Zinc'ing sensibly: controlling zinc homeostasis at the transcriptional level

Defect of zinc transporter ZRT1 ameliorates cadmium induced lipid accumulation in Saccharomyces cerevisiae

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