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| Content Provider | PubMed Central |
|---|---|
| Author | Streeck, Hendrik Nixon, Douglas F. |
| Abstract | Exceedingly high viral loads and rapid loss of CD4+ T cells in all tissue compartments is a hallmark of acute HIV-1 infection, which is often accompanied by clinical symptoms, such as fever, maculopapular rash and/or lymphadenopathy. The resolution of the clinical symptoms, and the subsequent decrease of plasma viremia are associated with the emergence of HIV-1-specific CD4+ and CD8+ T cell responses. The remarkable early inhibition of viremia by CD8+ T cells appears to be precipitated by only a limited number of specific CD8+ T cell responses, and the plasma viremia is reduced to a “set point” level. Over time the breadth and magnitude of CD8+ T cell responses increase, but without a change in the control of viral replication or further reduction in the viral set point. Moreover, the early viral set point, consequent upon the first CD8+ T cell responses, is highly predictive for the later course of disease progression. Thus, HIV-1-specific CD8+ T cell responses in acute HIV-1 infection appear to be uniquely able to efficiently suppress viral replication, while CD8+ T cell responses generated in the chronic phase of the infection appear often impaired. |
| Related Links | http://dx.doi.org/10.1086/655652 |
| Starting Page | 302 |
| File Format | |
| ISSN | 00221899 |
| e-ISSN | 15376613 |
| Journal | The Journal of infectious diseases |
| Issue Number | Suppl 2 |
| Volume Number | 202 |
| Language | English |
| Publisher Date | 2010-10-15 |
| Access Restriction | Open |
| Subject Keyword | Immunology and Allergy Infectious Diseases Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Allergy |
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