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T Cell Immunity in Acute HIV-1 Infection
| Content Provider | Paperity |
|---|---|
| Author | Streeck, Hendrik Nixon, Douglas F. |
| Abstract | Exceedingly high viral loads and rapid loss of CD4+ T cells in all tissue compartments are a hallmark of acute human immunodeficiency virus type 1 (HIV-1) infection, which is often accompanied by clinical symptoms such as fever, maculopapular rash, and/or lymphadenopathy. The resolution of the clinical symptoms and the subsequent decrease in plasma viremia are associated with the emergence of HIV-1-specific CD4+ and CD8+ T cell responses. The remarkable early inhibition of viremia by CD8++ T cells appears to be precipitated by only a limited number of specific CD8+ T cell responses, and the plasma viremia is reduced to a “set point” level. Over time, the breadth and magnitude of CD8+ T cell responses increase, but without a change in the control of viral replication or further reduction in the viral set point. Moreover, the early viral set point, consequent on the first CD8+ T cell responses, is highly predictive of the later course of disease progression. Thus, HIV-1-specific CD8+ T cell responses in acute HIV-1 infection appear uniquely able to efficiently suppress viral replication, whereas CD8+ T cell responses generated in the chronic phase of infection appear often impaired. |
| Starting Page | S302 |
| Ending Page | S308 |
| File Format | HTM / HTML |
| ISSN | 00221899 |
| DOI | 10.1086/655652 |
| Issue Number | 2 |
| Journal | Journal of Infectious Diseases |
| Volume Number | 202 |
| e-ISSN | 15376613 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2010-10-01 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Allergy |
