NDLI: Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts

Content Provider	PubMed Central
Author	Huang, Chih-fen Lira, Cristina Chu, Khoi Bilen, Mehmet Asim Lee, Yu-chen Ye, Xiangcang Kim, Soo Mi Ortiz, Angelica Lin, Wu Fe- Logothetis, Christopher J. Yu-lee, Li-yuan Lin, Sue-hwa
Abstract	Cell adhesion molecules have been implicated in the colonization of cancer cells to distant organs. Prostate cancer (PCa) has a propensity to metastasize to bone and cadherin-11, which is an osteoblast cadherin aberrantly expressed in PCa cells derived from bone metastases, has been shown to play a role in the metastasis of PCa cells to bone. However, the mechanism by which cadherin-11 is involved in this process is not known. Here, we show that expression of cadherin-11 in cadherin-11-negative C4-2B4 cells increases their spreading and intercalation into an osteoblast layer, and also stimulates C4-2B4 cell migration and invasiveness. Downregulation of cadherin-11 in cadherin-11-expressing metastatic PC3 cells decreases cell motility and invasiveness. Further, both the juxtamembrane (JMD) and β-catenin binding domains (CBS) in the cytoplasmic tail of cadherin-11 are required for cell migration and invasion, but not spreading. Gene array analyses showed that several invasion related genes, including MMP-7 and MMP-15, are upregulated in cadherin-11, but not in cad11-ΔJMD or cad11-ΔCBS, expressing C4-2B4 cells. These observations suggest that cadherin-11 not only provides a physical link between PCa cells and osteoblasts but also increases PCa cell motility and invasiveness that may facilitate the metastatic colonization of PCa cells in bone.
Related Links	http://dx.doi.org/10.1158/0008-5472.CAN-09-3016
Ending Page	4589
Page Count	10
Starting Page	4580
File Format	PDF
ISSN	15387445
e-ISSN	15387445
Journal	Cancer research
Issue Number	11
Volume Number	70
Language	English
Publisher Date	2010-06-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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