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| Content Provider | PubMed Central |
|---|---|
| Author | Passarella, Ralph J. Spratt, Daniel E. Ende, Alice E. Van Der Phillips, John G. Wu, Hongmei Vasanth, Sathiyakumar Zhou, Li Hallahan, Dennis E. Harth, Eva Diaz, Roberto |
| Abstract | To capitalize on the response of tumor cells to ionizing radiation, we developed a controlled-release nanoparticle drug delivery system using a targeting peptide that recognizes a radiation-induced cell surface receptor. Phage display biopanning identified Gly-Ile-Arg-Leu-Arg-Gly (GIRLRG) as a peptide that selectively recognizes tumors responding to ionizing radiation. Membrane protein extracts of irradiated glioma cells identified glucose-regulated protein GRP78 as the receptor target for GIRLRG. Antibodies to GRP78 blocked the binding of GIRLRG in vitro and in vivo. Conjugation of GIRLRG to a sustained-release nanoparticle drug delivery system yielded increased paclitaxel concentration and apoptosis in irradiated breast carcinomas for up to three weeks. Compared to controls, a single administration of the GIRLRG-targeted nanoparticle drug delivery system to irradiated tumors delayed the in vivo tumor tripling time by 55 days (P=0.0001) in MDA-MB-231, and 12 days in GL261 (P<0.005). This targeting agent combines a novel recombinant peptide with a paclitaxel encapsulating nanoparticle that specifically targets irradiated tumors, increasing apoptosis and tumor growth delay in a manner superior to known chemotherapy approaches. |
| Related Links | http://dx.doi.org/10.1158/0008-5472.can-10-0339 |
| Ending Page | 4559 |
| Page Count | 10 |
| Starting Page | 4550 |
| File Format | |
| ISSN | 00085472 |
| e-ISSN | 15387445 |
| Journal | Cancer research |
| Issue Number | 11 |
| Volume Number | 70 |
| Language | English |
| Publisher Date | 2010-06-01 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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