NDLI: WT1 and kidney progenitor cells

Content Provider	PubMed Central
Author	Kreidberg, Jordan A.
Copyright Year	2010
Abstract	Kidney development has been studied over the past sixty years as a model of embryonic induction during organogenesis. Wilms’ tumor-1 (WT1), that encodes a transcription factor and RNA-binding protein, was one of the first tumor suppressor genes identified, and was soon thereafter shown to be associated with syndromic forms of childhood kidney disease and gonadal dysgenesis. Kidney agenesis, resulting from a null mutation in the WT1 gene, was one of the first examples of organ agenesis resulting from a gene targeting experiment. Thus, the study of the WT1 gene and its encoded proteins has been at the forefront of developmental biology, tumor biology and the molecular basis for disease. WT1 is now known to have an important role in kidney progenitor cells during development. This review will discuss recent advances in our understanding of kidney progenitor cells, and the recent identification of WT1 target genes in these cells.
Starting Page	61
File Format	PDF
ISSN	15558592
e-ISSN	15558592
Journal	Organogenesis
Issue Number	2
Volume Number	6
Language	English
Publisher	Landes Bioscience
Publisher Date	2010-01-01
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Transplantation Embryology Biomedical Engineering

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WT1 and kidney progenitor cells