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Atlas-derived perfusion correlates of white matter hyperintensities in patients with reduced cardiac output

Content Provider	PubMed Central
Author	Jefferson, Angela L. Holland, Christopher M. Tate, David F. Csapo, Istvan Poppas, Athena Cohen, Ronald A. Guttmann, Charles R. G.
Abstract	Reduced cardiac output is associated with increased white matter hyperintensities (WMH) and executive dysfunction in older adults, which may be secondary to relations between systemic and cerebral perfusion. This study preliminarily describes the regional distribution of cerebral WMH in the context of a normal cerebral perfusion atlas and aims to determine if these variables are associated with reduced cardiac output. Thirty-two participants (72 ± 8 years old, 38% female) with cardiovascular risk factors or disease underwent structural MRI acquisition at 1.5 T using a standard imaging protocol that included FLAIR sequences. WMH distribution was examined in common anatomical space using voxel-based morphometry and as a function of normal cerebral perfusion patterns by overlaying a single photon emission computed tomography (SPECT) atlas. Doppler echocardiogram data was used to dichotomize the participants on the basis of low (n = 9) and normal (n = 23) cardiac output. Global WMH count and volume did not differ between the low and normal cardiac output groups; however, atlas-derived SPECT perfusion values in regions of hyperintensities were reduced in the low versus normal cardiac output group (p < 0.001). Our preliminary data suggest that participants with low cardiac output have WMH in regions of relatively reduced perfusion, while normal cardiac output participants have WMH in regions with relatively higher regional perfusion. This spatial perfusion distribution difference for areas of WMH may occur in the context of reduced systemic perfusion, which subsequently impacts cerebral perfusion and contributes to subclinical or clinical microvascular damage.
Related Links	http://dx.doi.org/10.1016/j.neurobiolaging.2009.01.011
Ending Page	139
Page Count	7
Starting Page	133
File Format	PDF
ISSN	01974580
e-ISSN	15581497
Journal	Neurobiology of aging
Issue Number	1
Volume Number	32
Language	English
Publisher Date	2011-01-01
Access Restriction	Open
Subject Keyword	Developmental Biology Ageing Neuroscience(all) Geriatrics and Gerontology Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Developmental Biology Aging Neurology (clinical) Geriatrics and Gerontology

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