NDLI: Altered Ca2+ homeostasis in the skeletal muscle of DJ

Content Provider	PubMed Central
Author	Alexander, Shtifman Zhong, Nan Lopez, Jose R. Shen, Jie Xu, Jin
Abstract	Loss-of-function mutations in DJ – 1 are associated with early-onset of Parkinson’s disease. Although DJ – 1 is ubiquitously expressed, the functional pathways affected by it remain unresolved. Here we demonstrate an involvement of DJ – 1 in the regulation of Ca2+ homeostasis in mouse skeletal muscle. Using enzymatically dissociated flexor digitorum brevis muscle fibers from wild-type (wt) and DJ – 1 null mice, we examined the effects of DJ – 1 protein on resting, cytoplasmic [Ca2+] ([Ca2+] i ) and depolarization-evoked Ca2+ release in the mouse skeletal muscle. The loss of DJ – 1 resulted in a more than two-fold increase in resting [Ca2+] i . While there was no alteration in the resting membrane potential, there was a significant decrease in depolarization-evoked Ca2+ release from the sarcoplasmic reticulum in the DJ – 1 null muscle cells. Consistent with the role of DJ – 1 in oxidative stress regulation and mitochondrial functional maintenance, treatments of DJ – 1 null muscle cells with resveratrol, a mitochondrial activator, or glutathione, a potent antioxidant, reversed the effects of the loss of DJ – 1 on Ca2+ homeostasis. These results provide evidence of DJ – 1’s association with Ca2+ regulatory pathways in mouse skeletal muscle, and suggest the potential benefit of resveratrol to functionally compensate for the loss of DJ – 1.
Related Links	http://dx.doi.org/10.1016/j.neurobiolaging.2009.07.010
Ending Page	132
Page Count	8
Starting Page	125
File Format	PDF
ISSN	01974580
e-ISSN	15581497
Journal	Neurobiology of aging
Issue Number	1
Volume Number	32
Language	English
Publisher Date	2011-01-01
Access Restriction	Open
Subject Keyword	Developmental Biology Ageing Neuroscience(all) Geriatrics and Gerontology Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Developmental Biology Aging Neurology (clinical) Geriatrics and Gerontology

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