NDLI: Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study

Content Provider	PubMed Central
Author	Van, Zaane Bregje Alessandro, Squizzato Huijgen, Roeland Zanten, Anton P. Van Eric, Fliers Cannegieter, Suzanne C. Büller, Harry R. Gerdes, Victor E. A. Brandjes, Dees P. M.
Abstract	A hypercoagulable state exists in hyperthyroidism, but the association with venous thrombosis (VT) is not fully explored. We aimed to investigate VT risk for different plasma levels of thyroid hormones and thyroid antibodies. We used a case-control study on leg vein thrombosis conducted between September 1999 and August 2006 at the Academic Medical Center, Amsterdam, The Netherlands. Parameters of thyroid function were assessed in 190 cases (mean age, 57 years; range, 19-90 years) and 379 sex-matched controls (mean age, 56 years; range, 18-93 years). Odds ratios (ORs) and 95% confidence intervals (CIs) for VT risk were estimated according to several cutoff levels derived from plasma levels observed in controls. We found the risk of VT to gradually rise with increasing levels of free thyroxine (FT4). In the absence of traditional acquired risk factors, FT4 levels above 17 pmol/L yielded a sex- and age-adjusted OR of 2.2 (95% CI, 1.2-4.2) for deep VT, which further increased up to an OR of 13.0 (95% CI, 1.1-154.1) for FT4 levels above reference range. Our data suggest increasing levels of FT4 to be a risk factor for VT and may have implications for both the prevention and management of this disease.
Related Links	http://dx.doi.org/10.1182/blood-2009-11-253724
Ending Page	4349
Page Count	6
Starting Page	4344
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	22
Volume Number	115
Language	English
Publisher	American Society of Hematology
Publisher Date	2010-06-03
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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