NDLI: Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

Please wait, while we are loading the content...

Year: 2016, Volume: 113

Year: 2015, Volume: 112

Year: 2014, Volume: 111

Year: 2013, Volume: 110

Year: 2012, Volume: 109

Year: 2011, Volume: 109

Year: 2011, Volume: 108

Year: 2010, Volume: 107

Year: 2009, Volume: 106

Year: 2009, Volume: 94

Year: 2008, Volume: 105

Year: 2007, Volume: 104

Year: 2006, Volume: 103

Year: 2005, Volume: 103

Year: 2005, Volume: 102

Year: 2004, Volume: 101

Year: 2003, Volume: 100

Year: 2002, Volume: 99

Year: 2001, Volume: 98

Year: 2000, Volume: 97

Year: 1999, Volume: 96

Year: 1998, Volume: 95

Year: 1997, Volume: 94

Year: 1996, Volume: 93

Year: 1995, Volume: 92

Year: 1994, Volume: 91

Year: 1993, Volume: 90

Year: 1992, Volume: 89

Year: 1991, Volume: 88

Year: 1990, Volume: 87

Year: 1989, Volume: 86

Year: 1988, Volume: 85

Year: 1988, Volume: 85, Issue: Suppl

Year: 1988, Volume: 85, Issue: 24

Year: 1988, Volume: 85, Issue: 23

Estimates for the ∂̄-Neumann problem for pseudoconvex domains in C2 of finite type

Milk lipid globules: control of their size distribution.

Energy metabolism of the untrained muscle of elite runners as observed by 31P magnetic resonance spectroscopy: evidence suggesting a genetic endowment for endurance exercise.

Determination of DNA structures by NMR and distance geometry techniques: a computer simulation.

Detection of nucleic acid hybridization by nonradiative fluorescence resonance energy transfer.

Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation.

DNA damage-inducible transcripts in mammalian cells.

Reduction of polygalacturonase activity in tomato fruit by antisense RNA

Identification of a unique isoform of 1-aminocyclopropane-1-carboxylic acid synthase by monoclonal antibody

Metal-specific synthesis of two metallothioneins and gamma-glutamyl peptides in Candida glabrata.

Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells.

NF-kappa B protein purification from bovine spleen: nucleotide stimulation and binding site specificity.

Evidence for a trans-acting factor that regulates the transcription of class II major histocompatibility complex genes: genetic and functional analysis.

Identification of phosphorylated 422(aP2) protein as pp15, the 15-kilodalton target of the insulin receptor tyrosine kinase in 3T3-L1 adipocytes.

Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.

Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta-lactoglobulins.

DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences.

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.

Beta gamma subunits of GTP-binding proteins inhibit muscarinic receptor stimulation of phospholipase C.

Reexamination of the kinetics of the transfer of NADH between its complexes with glycerol-3-phosphate dehydrogenase and with lactate dehydrogenase.

Adenosine regulates the Ca2+ sensitivity of mast cell mediator release.

His-426 of the Pseudomonas aeruginosa exotoxin A is required for ADP-ribosylation of elongation factor II.

Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc.

Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice.

A nuclease that cuts specifically in the ribosome binding site of some T4 mRNAs.

Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation.

Different structures in the amino-terminal domain of the ornithine transcarbamylase leader peptide are involved in mitochondrial import and carboxyl-terminal cleavage.

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei.

Phosphorylation of nitrogen regulator I (NRI) of Escherichia coli.

Cocrystal structure of an editing complex of Klenow fragment with DNA.

Identification and purification of a Drosophila protein that binds to the terminal 31-base-pair inverted repeats of the P transposable element.

Probing the Escherichia coli glnALG upstream activation mechanism in vivo.

Characterization of the minor groove environment in a drug-DNA complex: bisbenzimide bound to the poly[d(AT)].poly[d(AT)]duplex.

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.

SecA suppresses the temperature-sensitive SecY24 defect in protein translocation in Escherichia coli membrane vesicles.

Inhibition of H+-transporting ATPase by formation of a tight nucleoside diphosphate-fluoroaluminate complex at the catalytic site.

Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Dual mechanism of repression at a distance in the lac operon.

Promoters largely determine the efficiency of repressor action.

Purified secB protein of Escherichia coli retards folding and promotes membrane translocation of the maltose-binding protein in vitro.

Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin.

Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene.

Polyomavirus early-late switch is not regulated at the level of transcription initiation and is associated with changes in RNA processing.

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

Relationship between transient DNA hypomethylation and erythroid differentiation of murine erythroleukemia cells.

Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus.

Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: symmetry relations and sequence comparisons between different species.

Ca2+ transient, Mg2+, and pH measurements in the cardiac cycle by 19F NMR.

Two-dimensional protonic percolation on lightly hydrated purple membrane

Transformation of the cryobehavior of rye protoplasts by modification of the plasma membrane lipid composition

The dominant non-gibberellin-responding dwarf mutant (D8) of maize accumulates native gibberellins

Evidence for N- and C-terminal processing of a plant defense-related enzyme: Primary structure of tobacco prepro-β-1,3-glucanase

Evidence for expression of the facilitated glucose transporter in rat hepatocytes.

Decreased de novo synthesis of proteoglycans in drug-induced renal cystic disease.

Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin.

Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis.

Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells.

Deletion of transfected oncogenes from NIH 3T3 transformants by inhibitors of poly(ADP-ribose) polymerase.

cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity.

Conditional enhancement of liver-specific gene transcription.

Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: liver-specific expression in the rat.

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis.

Erythropoietin changes the globin program of an interleukin 3-dependent multipotential cell line.

Glucocorticoids both stimulate and inhibit production of pulmonary surfactant protein A in fetal human lung.

Tandemly repeated tRNA pseudogenes in photobacterium.

Analysis of pivotal-differential evolutionary patterns

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci.

Overproduction of the epsilon subunit of DNA polymerase III counteracts the SOS mutagenic response of Escherichia coli.

Evidence for a single rolling circle in the replication of potato spindle tuber viroid

Synthesis of an opine-like compound, a rhizopine, in alfalfa nodules is symbiotically regulated.

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

A sensitive molecular assay for mutagenesis in mammalian cells: reversion analysis in cells with a mutant shuttle vector gene integrated into chromosomal DNA.

Structure and chromosomal localization of the functional intronless human JUN protooncogene.

Intrachromosomal rearrangements mediated by hobo transposons in Drosophila melanogaster.

Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript.

Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.

High frequency of mosaic mutants produced by N-ethyl-N-nitrosourea exposure of mouse zygotes.

Analysis of a T-cell tumor-specific breakpoint cluster at human chromosome 14q32.

M13 repeat probe detects DNA minisatellite-like sequences in gymnosperms and angiosperms.

Release of IgD-binding factor by T cells under the influence of interleukin 2, interleukin 4, or cross-linked IgD.

An analysis of T-cell receptor variable region gene expression in major histocompatibility complex disparate mice.

Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones.

Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes.

Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor.

Anti-immunoglobulin pretreatment induces a calcium-mobilization response to the chemotactic agent N-formylmethionylleucylphenylalanine in Daudi lymphoblastoid cells.

Expression of CD3-associated antigen-binding receptors on suppressor T cells.

Formation of IgE-binding factors by T cells of patients infected with human immunodeficiency virus type 1.

Missense mutations in an infectious human immunodeficiency viral genome: functional mapping of tat and identification of the rev splice acceptor.

Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome.

Purification and characterization of a bovine acetyl low density lipoprotein receptor.

Detection of benzo[a]pyrene diol epoxide-DNA adducts in human placenta.

Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.

Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin.

Localization of human ERBA2 to the 3p22----3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer.

Even transcriptionally competent proviruses are silent in bovine leukemia virus-induced sheep tumor cells.

Analysis of RAS oncogene mutations in human lymphoid malignancies.

Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis.

Fetal hemoglobin synthesis in vivo: direct evidence for control at the level of erythroid progenitors.

Processing of the structural proteins of human immunodeficiency virus type 1 in the presence of monensin and cerulenin.

Juxtaposition of the T-cell receptor alpha-chain locus (14q11) and a region (14q32) of potential importance in leukemogenesis by a 14;14 translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia.

Reversion toward an earlier stage of differentiation and loss of polarity during progression of N-methyl-N-nitrosourea-induced rat mammary tumours.

Stress-induced alterations of immunity in hypophysectomized rats.

Aberrant expression of receptors for platelet-derived growth factor in an anaplastic thyroid carcinoma cell line.

Epstein-Barr virus (EBV) infection of murine L cells expressing recombinant human EBV/C3d receptor.

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

Characterization of invasion plasmid antigen genes (ipaBCD) from Shigella flexneri.

Mammalian cerebral cortical tissue responds to low-intensity visible light.

Suppression and induction of epileptic activity by neuronal grafts.

Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization.

Patch-clamp study of gamma-aminobutyric acid receptor Cl- channels in cultured astrocytes.

Measurement of local cerebral protein synthesis in vivo: influence of recycling of amino acids derived from protein degradation.

Long-term potentiation differentially affects two components of synaptic responses in hippocampus.

Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities.

Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7.

Guanosine 5'-monophosphate modulates gating of high-conductance Ca2+-activated K+ channels in vascular smooth muscle cells.

Vasopressin modulates the spontaneous electrical activity in aortic cells (line A7r5) by acting on three different types of ionic channels.

Classification of the European language families by genetic distance.

Year: 1988, Volume: 85, Issue: 22

Year: 1988, Volume: 85, Issue: 21

Year: 1988, Volume: 85, Issue: 20

Year: 1988, Volume: 85, Issue: 19

Year: 1988, Volume: 85, Issue: 18

Year: 1988, Volume: 85, Issue: 17

Year: 1988, Volume: 85, Issue: 16

Year: 1988, Volume: 85, Issue: 15

Year: 1988, Volume: 85, Issue: 14

Year: 1988, Volume: 85, Issue: 13

Year: 1988, Volume: 85, Issue: 12

Year: 1988, Volume: 85, Issue: 11

Year: 1988, Volume: 85, Issue: 10

Year: 1988, Volume: 85, Issue: 9

Year: 1988, Volume: 85, Issue: 8

Year: 1988, Volume: 85, Issue: 7

Year: 1988, Volume: 85, Issue: 6

Year: 1988, Volume: 85, Issue: 5

Year: 1988, Volume: 85, Issue: 4

Year: 1988, Volume: 85, Issue: 3

Year: 1988, Volume: 85, Issue: 2

Year: 1988, Volume: 85, Issue: 1

Year: 1987, Volume: 84

Year: 1986, Volume: 83

Year: 1985, Volume: 82

Year: 1984, Volume: 81

Year: 1983, Volume: 80

Year: 1982, Volume: 79

Year: 1981, Volume: 78

Year: 1980, Volume: 77

Year: 1979, Volume: 76

Year: 1978, Volume: 75

Year: 1977, Volume: 74

Year: 1976, Volume: 73

Year: 1975, Volume: 72

Year: 1974, Volume: 71

Year: 1973, Volume: 70

Year: 1972, Volume: 69

Year: 1971, Volume: 68

Year: 1970, Volume: 67

Year: 1970, Volume: 66

Year: 1970, Volume: 65

Year: 1969, Volume: 64

Year: 1969, Volume: 63

Year: 1969, Volume: 62

Year: 1968, Volume: 61

Year: 1968, Volume: 60

Year: 1968, Volume: 59

Year: 1967, Volume: 58

Year: 1967, Volume: 57

Year: 1966, Volume: 56

Year: 1966, Volume: 55

Year: 1965, Volume: 54

Year: 1965, Volume: 53

Year: 1964, Volume: 52

Year: 1964, Volume: 51

Year: 1963, Volume: 50

Year: 1963, Volume: 49

Year: 1962, Volume: 48

Year: 1961, Volume: 47

Year: 1960, Volume: 46

Year: 1959, Volume: 45

Year: 1958, Volume: 44

Year: 1957, Volume: 43

Year: 1956, Volume: 42

Year: 1955, Volume: 41

Year: 1954, Volume: 40

Year: 1953, Volume: 39

Year: 1952, Volume: 38

Year: 1951, Volume: 37

Year: 1950, Volume: 36

Year: 1949, Volume: 35

Year: 1948, Volume: 34

Year: 1947, Volume: 33

Year: 1946, Volume: 32

Year: 1945, Volume: 31

Year: 1944, Volume: 30

Year: 1943, Volume: 29

Year: 1942, Volume: 28

Year: 1941, Volume: 27

Year: 1940, Volume: 26

Year: 1939, Volume: 25

Year: 1938, Volume: 24

Year: 1937, Volume: 23

Year: 1936, Volume: 22

Year: 1935, Volume: 21

Year: 1934, Volume: 20

Year: 1933, Volume: 19

Year: 1932, Volume: 18

Year: 1931, Volume: 17

Year: 1930, Volume: 16

Year: 1929, Volume: 15

Year: 1928, Volume: 14

Year: 1927, Volume: 13

Year: 1926, Volume: 12

Year: 1925, Volume: 11

Year: 1924, Volume: 10

Year: 1923, Volume: 9

Year: 1922, Volume: 8

Year: 1921, Volume: 7

Year: 1920, Volume: 6

Year: 1919, Volume: 5

Year: 1918, Volume: 4

Year: 1917, Volume: 3

Year: 1916, Volume: 2

Year: 1915, Volume: 1

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

Content Provider	PubMed Central
Author	Morrison, D. K. Kaplan, D. R. Rapp, U. Roberts, T. M.
Abstract	We have examined the phosphorylation and the serine/threonine-specific kinase activity of the protooncogene product Raf-1 (formerly c-raf) in response to oncogenic transformation or growth-factor treatment of mouse 3T3 cells. Expression of the membrane-bound oncogene products encoded by v-fms, v-src, v-sis, polyoma virus middle-sized tumor antigen, and Ha-ras increased the apparent molecular weight and phosphorylation of the Raf-1 protein, while expression of the nuclear oncogene and protooncogene products encoded by v-fos and c-myc did not. Changes in electrophoretic mobility and phosphorylation occurred rapidly in response to treatment of cells with platelet-derived growth factor, acidic fibroblast growth factor, epidermal growth factor, and the protein kinase C activator phorbol 12-myristate 13-acetate, but not insulin. The phosphorylation of the Raf-1 protein occurred primarily on serine and threonine residues. However, a subpopulation of Raf-1 molecules was phosphorylated on tyrosine residues in cells transformed by v-src or stimulated with platelet-derived growth factor. Transformation by v-src, or treatment with platelet-derived growth factor or phorbol 12-myristate 13-acetate, activated the Raf-1-associated serine/kinase activity as measured in immune-complex kinase assays. These findings suggest that proliferative signals generated at the membrane result in the phosphorylation of the Raf-1 protein and the activation of its serine/threonine kinase activity. Raf-1 activation may thus serve to transduce signals from the membrane to the cytoplasm and perhaps on to the nucleus.
Starting Page	8855
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	85
Language	English
Publisher Date	1988-12-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in