NDLI: Comparison of gene expression profiles between human and mouse monocyte subsets

Content Provider	PubMed Central
Author	Ingersoll, Molly A. Rainer, Spanbroek Claudio, Lottaz Gautier, Emmanuel L. Frankenberger, Marion Hoffmann, Reinhard Lang, Roland Haniffa, Muzlifah Collin, Matthew Tacke, Frank Habenicht, Andreas J. R. Ziegler-heitbrock, Loems Randolph, Gwendalyn J.
Abstract	Blood of both humans and mice contains 2 main monocyte subsets. Here, we investigated the extent of their similarity using a microarray approach. Approximately 270 genes in humans and 550 genes in mice were differentially expressed between subsets by 2-fold or more. More than 130 of these gene expression differences were conserved between mouse and human monocyte subsets. We confirmed numerous of these differences at the cell surface protein level. Despite overall conservation, some molecules were conversely expressed between the 2 species' subsets, including CD36, CD9, and TREM-1. Other differences included a prominent peroxisome proliferator-activated receptor γ (PPARγ) signature in mouse monocytes, which is absent in humans, and strikingly opposed patterns of receptors involved in uptake of apoptotic cells and other phagocytic cargo between human and mouse monocyte subsets. Thus, whereas human and mouse monocyte subsets are far more broadly conserved than currently recognized, important differences between the species deserve consideration when models of human disease are studied in mice.
Related Links	http://dx.doi.org/10.1182/blood-2009-07-235028
Starting Page	10
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	3
Volume Number	115
Language	English
Publisher	American Society of Hematology
Publisher Date	2010-01-21
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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Ingersoll MA, Spanbroek R, Lottaz C, et al. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood. 2010;115(3):e10–e19.

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Ingersoll MA, Spanbroek R, Lottaz C, et al. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood. 2010;115(3):e10–e19.

Prediction of cytogenetic abnormalities with gene expression profiles

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Comparison of gene expression profiles between human and mouse monocyte subsets