NDLI: Regulating human Th17 cells via differential expression of IL-1 receptor

Content Provider	PubMed Central
Author	Lee, Won-woo Kang, Seong Wook Choi, Jihoon Lee, Seung-hyun Shah, Kamini Eynon, Elizabeth E. Flavell, Richard A. Kang, Insoo
Abstract	In humans, interleukin-1β (IL-1β) has been suggested as an essential cytokine for developing IL-17– or IL-17A–producing CD4+ T helper 17 (Th17) cells. However, little is known about the relationship of IL-1 receptor expression and Th17 cell differentiation. We report here the presence of 2 distinct CD4+ T-cell populations with and without expression of IL-1RI that correlates with the capacity to produce IL-17 in naive and memory CD4+ T cells of human peripheral blood. IL-1RI+ memory CD4+ T cells had increased gene expression of IL17, RORC, and IRF4 even before T-cell receptor triggering, indicating that the effect of IL-1β is programmed in these cells via IL-1RI. Although CD4+ T cells from umbilical cord blood did not express IL-1RI, the cytokines IL-7, IL-15, and transforming growth factor-β (TGF-β) up-regulated IL-1RI expression on naive CD4+ T cells, suggesting that IL-1RI+ naive CD4+ T cells develop in periphery. Furthermore, IL-17 production from the cytokine-treated naive CD4+ T cells was induced by IL-1β and this induction was blocked by IL-1R antagonist. These results indicate that human Th17 cell differentiation is regulated via differential expression of IL-1RI, which is controlled by IL-7 and IL-15.
Related Links	http://dx.doi.org/10.1182/blood-2009-08-236521
Ending Page	540
Page Count	11
Starting Page	530
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	3
Volume Number	115
Language	English
Publisher	American Society of Hematology
Publisher Date	2010-01-21
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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