NDLI: Naringenin Protects HaCaT Human Keratinocytes Against UVB-induced Apoptosis and Enhances the Removal of Cyclobutane Pyrimidine Dimers from the Genome†

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Naringenin Protects HaCaT Human Keratinocytes Against UVB-induced Apoptosis and Enhances the Removal of Cyclobutane Pyrimidine Dimers from the Genome†

Content Provider	PubMed Central
Author	El-mahdy, Mohamed A. Zhu, Qianzheng Wang, Qi-en Wani, Gulzar Patnaik, Srinivas Zhao, Qun Arafa, El-shaimaa Barakat, Bassant Mir, Safita N. Wani, Altaf A.
Copyright Year	2007
Abstract	Many naturally occurring agents are believed to protect against UV-induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB-induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53-mutant human keratinocyte HaCaT cells. The colony-forming assay shows that treatment with NG significantly increases long-term cell survival after UVB irradiation. NG treatment also protects the cells from UVB-induced apoptosis, as indicated by the absence of the 180 base pair DNA ladders and the appearance of sub-G1 peak using agarose gel electrophoresis and flow cytometric analysis, respectively. The UVB-induced poly (ADP-ribose) polymerase-1 (PARP-1) cleavage, caspase activation and Bax/Bcl2 ratio were modulated following NG treatment, indicating an antiapoptotic effect of NG in UVB-damaged cells that occurs at least in part via caspase cascade pathway. Moreover, treatment of UVB-irradiated HaCaT cells with NG enhances the removal of CPD from the genome, as observed by both direct quantitation of CPD in genomic DNA and immuno-localization of the damage within the nuclei. The study provides a molecular basis for the action of NG as a promising natural flavonoid in preventing skin aging and carcinogenesis.
Related Links	http://dx.doi.org/10.1111/j.1751-1097.2007.00255.x
Ending Page	316
Page Count	10
Starting Page	307
File Format	PDF
ISSN	00318655
Journal	Photochemistry and photobiology
Issue Number	2
Volume Number	84
Language	English
Publisher Date	2008-03-01
Access Restriction	Open
Subject Keyword	Physical and Theoretical Chemistry Biochemistry Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Physical and Theoretical Chemistry Radiation

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