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| Content Provider | PubMed Central |
|---|---|
| Author | Maheswari, Uma Mock, Thomas Armbrust, E. Virginia Bowler, Chris |
| Copyright Year | 2008 |
| Abstract | The Diatom Expressed Sequence Tag (EST) Database was constructed to provide integral access to ESTs from these ecologically and evolutionarily interesting microalgae. It has now been updated with 130 000 Phaeodactylum tricornutum ESTs from 16 cDNA libraries and 77 000 Thalassiosira pseudonana ESTs from seven libraries, derived from cells grown in different nutrient and stress regimes. The updated relational database incorporates results from statistical analyses such as log-likelihood ratios and hierarchical clustering, which help to identify differentially expressed genes under different conditions, and allow similarities in gene expression in different libraries to be investigated in a functional context. The database also incorporates links to the recently sequenced genomes of P. tricornutum and T. pseudonana, enabling an easy cross-talk between the expression pattern of diatom orthologs and the genome browsers. These improvements will facilitate exploration of diatom responses to conditions of ecological relevance and will aid gene function identification of diatom-specific genes and in silico gene prediction in this largely unexplored class of eukaryotes. The updated Diatom EST Database is available at http://www.biologie.ens.fr/diatomics/EST3. |
| Related Links | http://dx.doi.org/10.1093/nar/gkn905 |
| Starting Page | 1001 |
| File Format | |
| ISSN | 03051048 |
| e-ISSN | 13624962 |
| Journal | Nucleic Acids Research |
| Issue Number | Database issue |
| Volume Number | 37 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2009-01-01 |
| Access Restriction | Open |
| Rights Holder | Oxford University Press |
| Subject Keyword | Genetics Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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