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| Content Provider | PubMed Central |
|---|---|
| Author | Jung, Da-yeon Kim, Eun-young Joo, Sung-yeon Park, Jae Berm Moon, Cheol Kim, Sa Hyun Sim, Eun-young Joh, Jae-won Kwon, Choon Hyuck Kwon, Ghee-young Kim, Sung-joo |
| Copyright Year | 2008 |
| Abstract | Pancreatic islet transplantation can correct the abnormal glucose metabolism of Type 1 diabetes. Although immunosuppressants greatly reduce the acute rejection rate in transplant patients, the long-term side effects can be debilitating. Therefore, researchers are seeking to develop new immunosuppressive regimens that induce maximal levels of immunosuppression with minor side effects. Rosmarinic acid (Ros A) is a secondary metabolite of certain herbs and has multiple biological activities, including anti-inflammatory effects. Here, we have investigated whether treatment of mice with a combination of Ros A and anti-CD154 monoclonal antibody (MR1) improves islet allograft survival in a murine model. After transplantation, the mice were treated with either Ros A, MR1, or both (the "double" treatment). Allograft survival was prolonged in the double-treated animals compared to animals that received only Ros A or MR1. As is the case with the single-treated animals at 15 days after transplantation, the double-treated recipients did not display a significant decrease in the expression of cytokines or the population of activated T cells. Infiltrating CD3+ T cells were reduced in the MR1- or double therapy relative to control or RosA group. However, at the same time point, double-treated graft showed fewer apoptotic cells and increased expression of insulin and glucagons, compared to the single-treatment groups. Furthermore, long-term (> 150 days) allografts that were received with double therapy exhibited larger islet clusters and contained more insulin- and glucagon-positive cells, relative to the MR1-treated grafts. In conclusion, treatment with both Ros A and MR1 has a synergistic effect in murine islet allotransplantation. |
| Related Links | http://dx.doi.org/10.3858/emm.2008.40.1.1 |
| Starting Page | 1 |
| File Format | |
| ISSN | 12263613 |
| Journal | Experimental & Molecular Medicine |
| Issue Number | 1 |
| Volume Number | 40 |
| Language | English |
| Publisher | Korean Society of Medical Biochemistry and Molecular Biology |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Rights Holder | Korean Society of Medical Biochemistry and Molecular Biology |
| Subject Keyword | Clinical Biochemistry Molecular Medicine Biochemistry Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Molecular Biology Clinical Biochemistry Molecular Medicine |
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