NDLI: Krox20 Controls the Transcription of Its Various Targets in the Developing Hindbrain According to Multiple Modes* S⃞

Content Provider	PubMed Central
Author	Desmazières, Anne Charnay, Patrick Pascale, Gilardi-hebenstreit
Abstract	The zinc finger transcription factor Krox20 plays an essential role in the vertebrate hindbrain segmentation process. It positively or negatively controls a large variety of other regulatory genes, coordinating delimitation of segmental territories, specification of their identity, and maintenance of their integrity. We have investigated the molecular mechanisms of Krox20 transcriptional control by performing a detailed structure-function analysis of the protein in the developing chick hindbrain. This revealed an unsuspected diversity in the modes of action of a transcription factor in a single tissue, since regulation of each of the five tested target genes requires different parts of the protein and/or presumably different co-factors. The multiplicity of Krox20 functions might rely on this diversity. Investigation of known Krox20 co-factors was initiated in relation to this analysis. Nab was shown to act as a negative feedback modulator of the different Krox20 activating functions in the hindbrain. HCF-1 was found to bind to a Krox20 N-terminal region, which was shown to rely on multiple elements, including acidic domains, to convey Nab activation and Krox20 autoregulation.
Related Links	http://dx.doi.org/10.1074/jbc.m808683200
Ending Page	10840
Page Count	10
Starting Page	10831
File Format	PDF
ISSN	00219258
e-ISSN	1083351X
Journal	The Journal of Biological Chemistry
Issue Number	16
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology
Publisher Date	2009-02-01
Access Restriction	Open
Rights Holder	American Society for Biochemistry and Molecular Biology
Subject Keyword	Cell Biology Biochemistry Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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Krox20 Controls the Transcription of Its Various Targets in the Developing Hindbrain According to Multiple Modes

Krox20 controls the transcription of its various targets in the developing hindbrain according to multiple modes.

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Krox20 Controls the Transcription of Its Various Targets in the Developing Hindbrain According to Multiple Modes

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