NDLI: An examination of the synergy of pain and PTSD on quality of life: Additive or multiplicative effects?

Content Provider	PubMed Central
Author	Clapp, Joshua D. Beck, J. Gayle Palyo, Sarah A. Grant, Demond M.
Abstract	Although models have been proposed to explain common factors that maintain comorbid pain and PTSD [41], the exact nature of the relationship between these two conditions and their impact on quality of life (QOL) is unknown. The aim of the present investigation was to examine the unique and interactive effects of PTSD and pain on role functioning and life satisfaction - two important domains of QOL. The study utilized a help-seeking sample of motor vehicle accident (MVA) survivors whose accidents resulted in symptoms of comorbid PTSD and pain (N = 192). Hierarchical regression models were used to examine the relationship between four PTSD symptom clusters, pain, and the interaction of each cluster and pain on role functioning and life satisfaction separately. Results of these analyses revealed a significant interaction of pain and emotional numbing on role functioning, suggesting a multiplicative effect on this domain of QOL. Decomposition of this interaction revealed a negative association between numbing and functioning at low levels of pain but no relationship at higher levels. A marginal interaction of pain and hyperarousal also was noted for life satisfaction. Decomposition of the interaction effect revealed a marginal association between hyperarousal and decreased satisfaction only at high levels of pain. A main effect of emotional numbing on decreased life satisfaction also was observed in this model, suggesting a unique influence of numbing. The results of the current research indicate that the synergistic relationship of pain and PTSD may vary across domains of QOL.
Related Links	http://dx.doi.org/10.1016/j.pain.2008.01.001
Ending Page	309
Page Count	9
Starting Page	301
File Format	PDF
ISSN	03043959
e-ISSN	18726623
Journal	Pain
Issue Number	2
Volume Number	138
Language	English
Publisher Date	2008-08-01
Access Restriction	Open
Subject Keyword	Anesthesiology and Pain Medicine Pharmacology Neurology Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical) Pharmacology Anesthesiology and Pain Medicine

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