NDLI: LYRIC/AEG-1 overexpression modulates BCCIPα protein levels in prostate tumor cells

Content Provider	PubMed Central
Author	Ash, Sc Yang, Dq Britt, De
Abstract	LYRIC/AEG-1 is a unique protein that has been shown to promote tumor cell migration and invasion through activation of the transcription factor NF-κB. We performed yeast two-hybrid screening to detect LYRIC/AEG-1 associated proteins, and identified BCCIP, a CDKN1A and BRCA2-associated protein involved in cell cycle regulation and DNA repair. Here we demonstrate association between LYRIC/AEG-1 and BCCIP in mammalian cells, and define the region of interaction. Co-expression of the two proteins resulted in decreased levels of BCCIPα, an effect partially abrogated by proteasome inhibition. A truncated LYRIC/AEG-1 construct lacking the interaction region did not alter BCCIPα protein levels. Coincidentally, it was observed that overexpression of BCCIPα in DU145 prostate tumor cells induced an apparent neuroendocrine differentiation. In summary, our data suggest LYRIC/AEG-1 is a negative regulator of BCCIPα, promoting proteasomal degradation either through direct interaction, or potentially through an indirect mechanism involving downstream effects of the NF-κB signaling pathway.
Related Links	http://dx.doi.org/10.1016/j.bbrc.2008.04.084
Ending Page	338
Page Count	6
Starting Page	333
File Format	PDF
ISSN	0006291X
e-ISSN	10902104
Journal	Biochemical and biophysical research communications
Issue Number	2
Volume Number	371
Language	English
Publisher Date	2008-06-01
Access Restriction	Open
Subject Keyword	Biophysics Cell Biology Biochemistry Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Biochemistry Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

miR-21 coordinates tumor growth and modulates KRIT1 levels

Plasmalemmal vesicle associated protein (PV1) modulates SV40 virus infectivity in CV-1 cells

The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma

Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells

AEG-1/MTDH/LYRIC: Signaling Pathways, Downstream Genes, Interacting Proteins, and Regulation of Tumor Angiogenesis

AEG-1/MTDH/LYRIC: Clinical Significance

The ErbB3-binding protein EBP1 modulates lapatinib sensitivity in prostate cancer cells

Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate tumor derived LNCaP cell line

AEG-1/MTDH/LYRIC in Liver Cancer

LYRIC/AEG-1 overexpression modulates BCCIPα protein levels in prostate tumor cells

Similar Documents

miR-21 coordinates tumor growth and modulates KRIT1 levels

Plasmalemmal vesicle associated protein (PV1) modulates SV40 virus infectivity in CV-1 cells

The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma

Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells

AEG-1/MTDH/LYRIC: Signaling Pathways, Downstream Genes, Interacting Proteins, and Regulation of Tumor Angiogenesis

AEG-1/MTDH/LYRIC: Clinical Significance

The ErbB3-binding protein EBP1 modulates lapatinib sensitivity in prostate cancer cells

Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate tumor derived LNCaP cell line

AEG-1/MTDH/LYRIC in Liver Cancer

LYRIC/AEG-1 overexpression modulates BCCIPα protein levels in prostate tumor cells