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| Content Provider | PubMed Central |
|---|---|
| Author | Pavan, Adiseshaiah Li, Jinfang Vaz, Michelle Kalvakolanu, Dhananjaya V. Reddy, Sekhar P. |
| Abstract | Fra-1 as an integral part of AP-1 (Jun/Fos) drives transcriptional programs involved in several physiologic and pathologic processes. It is also critical for tumor cell motility and metastasis. We have previously shown that two critical elements of Fra-1 promoter, the upstream TPA response element (TRE) and the SRE are necessary for its induction in response to phorbol esters in human pulmonary epithelial cell lines. Here, we have investigated the roles of various MAP kinases in regulating Fra-1 expression in response to TPA. Using pharmacologic and genetic tools, we demonstrate a prominent role for ERK1/2, but not JNK1/2 and p38, signaling in the TPA-induced activation of specific transcription factors that bind to the AP1 site and the SRE. Inhibition of ERK1/2 pathway suppresses Elk1 activation, and c-Jun and Fra-2 recruitment to the promoter. |
| Related Links | http://dx.doi.org/10.1016/j.bbrc.2008.04.063 |
| Starting Page | 304 |
| File Format | |
| ISSN | 10902104 |
| e-ISSN | 10902104 |
| Journal | Biochemical and biophysical research communications |
| Issue Number | 2 |
| Volume Number | 371 |
| Language | English |
| Publisher Date | 2008-06-27 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Biochemistry Biophysics |
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