NDLI: Identification and Characterization of Two Novel Staphylococcal Enterotoxins, Types S and T▿

Content Provider	PubMed Central
Author	Ono, Hisaya K. Omoe, Katsuhiko Imanishi, Ken'ichi Iwakabe, Yoshihiro Hu, Dong-liang Kato, Hidehito Saito, Naoyuki Nakane, Akio Uchiyama, Takehiko Shinagawa, Kunihiro
Abstract	In addition to two known staphylococcal enterotoxin-like genes (selj and selr), two novel genes coding for two superantigens, staphylococcal enterotoxins S and T (SES and SET), were identified in plasmid pF5, which is harbored by food poisoning-related Staphylococcus aureus strain Fukuoka 5. This strain was implicated in a food poisoning incident in Fukuoka City, Japan, in 1997. Recombinant SES (rSES) specifically stimulated human T cells in a T-cell receptor Vβ9- and Vβ16-specific manner in the presence of major histocompatibility complex (MHC) class II+ antigen-presenting cells (APC). rSET also stimulated T cells in the presence of MHC class II+ APC, although its Vβ skewing was not found in reactive T cells. Subsequently, we examined the emetic activity of SES and SET. We also studied SElR to determine emetic activity in primates. This toxin was identified in previous studies but was not examined in terms of possession of emetic activity for primates. rSES induced emetic reactions in two of four monkeys at a dose of 100 μg/kg within 5 h of intragastric administration. In one monkey, rSET induced a delayed reaction (24 h postadministration) at a dose of 100 μg/kg, and in the other one, the reaction occurred 5 days postadministration. rSElR induced a reaction in two of six animals within 5 h at 100 μg/kg. On this basis, we speculate that the causative toxins of vomiting in the Fukuoka case are SES and SER. Additionally, SES, SER, and SET also induced emesis in house musk shrews as in the monkeys.
Related Links	http://dx.doi.org/10.1128/iai.00045-08
Ending Page	5005
Page Count	7
Starting Page	4999
File Format	PDF
ISSN	00199567
e-ISSN	10985522
Journal	Infection and Immunity
Issue Number	11
Volume Number	76
Language	English
Publisher	American Society for Microbiology (ASM)
Publisher Date	2008-11-01
Access Restriction	Open
Rights Holder	American Society for Microbiology (ASM)
Subject Keyword	Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Identification of a Transcytosis Epitope on Staphylococcal Enterotoxins

Characterization of novel type C staphylococcal enterotoxins: biological and evolutionary implications.

Identification and Characterization of Staphylococcal Enterotoxin Types G and I from Staphylococcus aureus

Identification and Characterization of a New Staphylococcal Enterotoxin-Related Putative Toxin Encoded by Two Kinds of Plasmids

Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins.

Vbeta-dependent stimulation of bovine and human T cells by host-specific staphylococcal enterotoxins.

Antigenic Cross-Reactivity of Staphylococcal Enterotoxins

Characterization of Novel Staphylococcal Enterotoxin-Like Toxin Type P

Induction of Emetic Response to Staphylococcal Enterotoxins in the House Musk Shrew (Suncus murinus)

Identification and Characterization of Two Novel Staphylococcal Enterotoxins, Types S and T▿

Similar Documents

Identification of a Transcytosis Epitope on Staphylococcal Enterotoxins

Characterization of novel type C staphylococcal enterotoxins: biological and evolutionary implications.

Identification and Characterization of Staphylococcal Enterotoxin Types G and I from Staphylococcus aureus

Identification and Characterization of a New Staphylococcal Enterotoxin-Related Putative Toxin Encoded by Two Kinds of Plasmids

Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins.

Vbeta-dependent stimulation of bovine and human T cells by host-specific staphylococcal enterotoxins.

Antigenic Cross-Reactivity of Staphylococcal Enterotoxins

Characterization of Novel Staphylococcal Enterotoxin-Like Toxin Type P

Induction of Emetic Response to Staphylococcal Enterotoxins in the House Musk Shrew (Suncus murinus)

Identification and Characterization of Two Novel Staphylococcal Enterotoxins, Types S and T▿