NDLI: Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons

Content Provider	PubMed Central
Author	Zhang, Dao-qi Wong, Kwoon Y. Sollars, Patricia J. Berson, David M. Pickard, Gary E. Mcmahon, Douglas G.
Abstract	Retinal dopaminergic amacrine neurons (DA neurons) play a central role in reconfiguring retinal function according to prevailing illumination conditions, yet the mechanisms by which light regulates their activity are poorly understood. We investigated the means by which sustained light responses are evoked in DA neurons. Sustained light responses were driven by cationic currents and persisted in vitro and in vivo in the presence of L-AP4, a blocker of retinal ON-bipolar cells. Several characteristics of these L-AP4-resistant light responses suggested that they were driven by melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), including long latencies, marked poststimulus persistence, and a peak spectral sensitivity of 478 nm. Furthermore, sustained DA neuron light responses, but not transient DA neuron responses, persisted in rod/cone degenerate retinas, in which ipRGCs account for virtually all remaining retinal phototransduction. Thus, ganglion-cell photoreceptors provide excitatory drive to DA neurons, most likely by way of the coramification of their dendrites and the processes of DA neurons in the inner plexiform layer. This unprecedented centrifugal outflow of ganglion-cell signals within the retina provides a novel basis for the restructuring of retinal circuits by light.
Related Links	http://dx.doi.org/10.1073/pnas.0803893105
Ending Page	14186
Page Count	6
Starting Page	14181
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	37
Volume Number	105
Language	English
Publisher	National Academy of Sciences
Publisher Date	2008-09-16
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

NMDA Receptors Contribute to Retrograde Synaptic Transmission from Ganglion Cell Photoreceptors to Dopaminergic Amacrine Cells

Dopaminergic modulation of ganglion-cell photoreceptors

Dopaminergic modulation of tracer coupling in a ganglion-amacrine cell network

Ectopic Retinal ON Bipolar Cell Synapses in the OFF Inner Plexiform Layer: Contacts with Dopaminergic Amacrine Cells and Melanopsin Ganglion Cells

Hyperpolarization-Activated Current (I h) in Ganglion-Cell Photoreceptors

Direct conversion of human fibroblasts to dopaminergic neurons

Amplification of dopaminergic signaling by a positive feedback loop

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity

Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons

Similar Documents

NMDA Receptors Contribute to Retrograde Synaptic Transmission from Ganglion Cell Photoreceptors to Dopaminergic Amacrine Cells

Dopaminergic modulation of ganglion-cell photoreceptors

Dopaminergic modulation of tracer coupling in a ganglion-amacrine cell network

Ectopic Retinal ON Bipolar Cell Synapses in the OFF Inner Plexiform Layer: Contacts with Dopaminergic Amacrine Cells and Melanopsin Ganglion Cells

Hyperpolarization-Activated Current (I h) in Ganglion-Cell Photoreceptors

Direct conversion of human fibroblasts to dopaminergic neurons

Amplification of dopaminergic signaling by a positive feedback loop

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity

Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons