NDLI: Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates

Content Provider	PubMed Central
Author	Klempa, Boris Meisel, Helga Räth, Silvana Bartel, Jan Ulrich, Rainer Krüger, Detlev H.
Copyright Year	2003
Abstract	Hantavirus species Tula (TULV) is carried by European common voles (Microtus spp.). Its pathogenic potential for humans is unknown. In a rural region of northeast Germany, a 43-year-old man became ill with fever, renal syndrome, and pneumonia. Typing of late acute- and convalescent-phase sera by focus reduction neutralization assay revealed the presence of neutralizing antibodies against TULV. Moreover, we detected TULV genetic material in Microtus arvalis animals that were trapped at places only a few kilometers from the home village of the patient. Phylogenetic analysis of completely sequenced genomic S segments from three virus strains grouped them within a third genetic lineage of the TULV species. This is the first case of hemorrhagic fever with renal syndrome and pulmonary involvement which can be associated with TULV infection.
Related Links	http://dx.doi.org/10.1128/JCM.41.10.4894-4897.2003
Starting Page	4894
File Format	PDF
ISSN	1098660X
e-ISSN	1098660X
Journal	Journal of Clinical Microbiology
Issue Number	10
Volume Number	41
Language	English
Publisher	American Society for Microbiology
Publisher Date	2003-10-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Microbiology (medical)

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Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates