NDLI: The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons

Content Provider	PubMed Central
Author	Deininger, Katrin Eder, Matthias Kramer, Edgar R. Walter, Zieglgänsberger Dodt, Hans-ulrich Klaus, Dornmair John, Colicelli Klein, Rüdiger
Abstract	Ephrin signaling through Eph receptor tyrosine kinases regulates important morphogenetic events during development and synaptic plasticity in the adult brain. Although Eph-ephrin endocytosis is required for repulsive axon guidance, its role in postnatal brain and synaptic plasticity is unknown. Here, we show that Rin1, a postnatal brain-specific Rab5-GEF, is coexpressed with EphA4 in excitatory neurons and interacts with EphA4 in synaptosomal fractions. The interaction of Rin1 and EphA4 requires Rin1's SH2 domain, consistent with the view that Rin1 targets tyrosine phosphorylated receptors to Rab5 compartments. We find that Rin1 mediates EphA4 endocytosis in postnatal amygdala neurons after engagement of EphA4 with its cognate ligand ephrinB3. Rin1 was shown to suppress synaptic plasticity in the amygdala, a forebrain structure important for fear learning, possibly by internalizing synaptic receptors. We find that the EphA4 receptor is required for synaptic plasticity in the amygdala, raising the possibility that an underlying mechanism of Rin1 function in amygdala is to down-regulate EphA4 signaling by promoting its endocytosis.
Related Links	http://dx.doi.org/10.1073/pnas.0801174105
Ending Page	12544
Page Count	6
Starting Page	12539
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	34
Volume Number	105
Language	English
Publisher	National Academy of Sciences
Publisher Date	2008-08-26
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases

The RAS Effector RIN1 Modulates Endocytosis via Activation of RAB5 GTPases and ABL Tyrosine Kinases

RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR

Nerve growth factor regulates the action potential duration of mature sensory neurons.

The Src Homology 2 Domain of Rin1 Mediates Its Binding to the Epidermal Growth Factor Receptor and Regulates Receptor Endocytosis

EphA4 defines a class of excitatory locomotor-related interneurons

RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases

rab5 GTPase Regulates Adenovirus Endocytosis

Inhibition of Rab5 Activation During Insulin Receptor-Mediated Endocytosis

The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons

Similar Documents

RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases

The RAS Effector RIN1 Modulates Endocytosis via Activation of RAB5 GTPases and ABL Tyrosine Kinases

RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR

Nerve growth factor regulates the action potential duration of mature sensory neurons.

The Src Homology 2 Domain of Rin1 Mediates Its Binding to the Epidermal Growth Factor Receptor and Regulates Receptor Endocytosis

EphA4 defines a class of excitatory locomotor-related interneurons

RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases

rab5 GTPase Regulates Adenovirus Endocytosis

Inhibition of Rab5 Activation During Insulin Receptor-Mediated Endocytosis

The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons