NDLI: Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region

Content Provider	PubMed Central
Author	Shiina, Takashi Tamiya, Gen Oka, Akira Takishima, Nobusada Yamagata, Tetsushi Kikkawa, Eri Iwata, Kyoko Tomizawa, Maiko Noriko, Okuaki Kuwano, Yuko Watanabe, Koji Fukuzumi, Yasuhito Itakura, Shoko Sugawara, Chiyo Ono, Ayako Yamazaki, Masaaki Tashiro, Hiroyuki Ando, Asako Ikemura, Toshimichi Soeda, Eiichi Kimura, Minoru Bahram, Seiamak Inoko, Hidetoshi
Copyright Year	1999
Abstract	The intensely studied MHC has become the paradigm for understanding the architectural evolution of vertebrate multigene families. The 4-Mb human MHC (also known as the HLA complex) encodes genes critically involved in the immune response, graft rejection, and disease susceptibility. Here we report the continuous 1,796,938-bp genomic sequence of the HLA class I region, linking genes between MICB and HLA-F. A total of 127 genes or potentially coding sequences were recognized within the analyzed sequence, establishing a high gene density of one per every 14.1 kb. The identification of 758 microsatellite provides tools for high-resolution mapping of HLA class I-associated disease genes. Most importantly, we establish that the repeated duplication and subsequent diversification of a minimal building block, MIC-HCGIX-3.8–1-P5-HCGIV-HLA class I-HCGII, engendered the present-day MHC. That the currently nonessential HLA-F and MICE genes have acted as progenitors to today’s immune-competent HLA-ABC and MICA/B genes provides experimental evidence for evolution by “birth and death,” which has general relevance to our understanding of the evolutionary forces driving vertebrate multigene families.
Starting Page	13282
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	96
Language	English
Publisher	The National Academy of Sciences
Publisher Date	1999-11-09
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region