NDLI: Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes.

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Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase.

Evidence for a functional subclass of the RTVL-H family of human endogenous retrovirus-like sequences.

EBNA-2 of herpesvirus papio diverges significantly from the type A and type B EBNA-2 proteins of Epstein-Barr virus but retains an efficient transactivation domain with a conserved hydrophobic motif.

Neutralizing linear epitopes of B19 parvovirus cluster in the VP1 unique and VP1-VP2 junction regions.

RNA duplex unwinding activity of poliovirus RNA-dependent RNA polymerase 3Dpol.

Prolonged replication in the mouse central nervous system of reoviruses isolated from persistently infected cell cultures.

Modification of eukaryotic initiation factor 4F during infection by influenza virus.

Analysis of transcription factors binding to the duplicated PEA1 and PEA3 sites that are required for polyomavirus mutant expression in PCC4 embryonic carcinoma cells.

Role of conserved glycosylation sites in maturation and transport of influenza A virus hemagglutinin.

Molecular comparison of the structural proteins encoding gene clusters of two related Lactobacillus delbrueckii bacteriophages.

Fowlpox virus recombinants expressing the envelope glycoprotein of an avian reticuloendotheliosis retrovirus induce neutralizing antibodies and reduce viremia in chickens.

Truncations of the simian immunodeficiency virus transmembrane protein confer expanded virus host range by removing a block to virus entry into cells.

Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes.

Synthesis and assembly of hepatitis A virus-specific proteins in BS-C-1 cells.

A small highly basic protein is encoded in overlapping frame within the P gene of vesicular stomatitis virus.

Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53.

Recombinant feline leukemia virus genes detected in naturally occurring feline lymphosarcomas.

Postabsorption neutralization of poliovirus.

The mitogenic activity of human T-cell leukemia virus type I is T-cell associated and requires the CD2/LFA-3 activation pathway.

Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding.

Alteration of location of dimer linkage sequence in retroviral RNA: little effect on replication or homologous recombination.

Rotavirus protein NSP3 (NS34) is bound to the 3' end consensus sequence of viral mRNAs in infected cells.

Definition of a subset of human peripheral blood mononuclear cells that are permissive to human cytomegalovirus infection.

Endogenous expression of E1A in human cells enhances the effect of adenovirus E3 on class I major histocompatibility complex antigen expression.

Hybrid human immunodeficiency virus Gag particles as an antigen carrier system: induction of cytotoxic T-cell and humoral responses by a Gag:V3 fusion.

Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes.

Immunological cross-reactions and interactions between the Drosophila melanogaster ref(2)P protein and sigma rhabdovirus proteins.

Complex nature of the major viral polyadenylated transcripts in Epstein-Barr virus-associated tumors.

Regulated splicing of adenovirus type 5 E4 transcripts and regulated cytoplasmic accumulation of E4 mRNA.

Analysis of the BZLF1 promoter of Epstein-Barr virus: identification of an anti-immunoglobulin response sequence.

Identification of tRNAs incorporated into wild-type and mutant human immunodeficiency virus type 1.

An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsidation.

Characterization of a temperature-sensitive influenza B virus mutant defective in neuraminidase.

Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef.

Ribonucleoprotein complexes of hepatitis delta virus.

Processing of the envelope glycoproteins of pestiviruses.

Contributions of the brome mosaic virus RNA-3 3'-nontranslated region to replication and translation.

Effect of intergenic consensus sequence flanking sequences on coronavirus transcription.

Hemagglutinin-neuraminidase enhances F protein-mediated membrane fusion of reconstituted Sendai virus envelopes with cells.

Dissociation of progeny vaccinia virus from the cell membrane is regulated by a viral envelope glycoprotein: effect of a point mutation in the lectin homology domain of the A34R gene.

Interchangeability of the adsorption proteins of bacteriophages Ff and IKe.

Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism.

Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection.

Experimental transmission of human hepatitis delta virus to the laboratory mouse.

Sindbis virus attachment: isolation and characterization of mutants with impaired binding to vertebrate cells.

Spontaneous and differentiation-dependent regulation of measles virus gene expression in human glial cells.

Adenovirus precursor to terminal protein interacts with the nuclear matrix in vivo and in vitro.

Inhibition of growth, transformation, and expression of human papillomavirus type 16 E7 in human keratinocytes by alpha interferons.

Herpetic stromal keratitis in the reconstituted scid mouse model.

Cross-reactive lysis of human targets infected with prototypic and clinical human immunodeficiency virus type 1 (HIV-1) strains by murine anti-HIV-1 IIIB env-specific cytotoxic T lymphocytes.

Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replication.

Genetic definition of a new bovine papillomavirus type 1 open reading frame, E5B, that encodes a hydrophobic protein involved in altering host-cell protein processing.

The vaccinia virus 14-kilodalton fusion protein forms a stable complex with the processed protein encoded by the vaccinia virus A17L gene.

Juxtaposition between activation and basic domains of human immunodeficiency virus type 1 Tat is required for optimal interactions between Tat and TAR.

Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis.

Hepatitis B virus differentially suppresses myelopoiesis and displays tropism for immature hematopoietic cells.

Selective interference with class I major histocompatibility complex presentation of the major immediate-early protein following infection with human cytomegalovirus.

Herpes simplex virus type 1 DNA cleavage and encapsidation require the product of the UL28 gene: isolation and characterization of two UL28 deletion mutants.

Identification and characterization of lef-1, a baculovirus gene involved in late and very late gene expression.

Mutational analysis of the envelope gene of Moloney murine leukemia virus.

Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T-cell clone specific for an envelope glycoprotein epitope of Lassa virus.

The adenovirus L3 23-kilodalton proteinase cleaves the amino-terminal head domain from cytokeratin 18 and disrupts the cytokeratin network of HeLa cells.

Characterization and temporal regulation of mRNAs encoded by vaccinia virus intermediate-stage genes.

Transformation-associated cytokine 9E3/CEF4 is chemotactic for chicken peripheral blood mononuclear cells.

Mutational analysis of the central domain of adenovirus virus-associated RNA mandates a revision of the proposed secondary structure.

cis-acting requirements for the replication of flock house virus RNA 2.

Secondary structure of gp160 and gp120 envelope glycoproteins of human immunodeficiency virus type 1: a Fourier transform infrared spectroscopic study.

Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.

Release of human immunodeficiency virus by THP-1 cells and human macrophages is regulated by cellular adherence and activation.

Genetic heterogeneity among isolates of Ross River virus from different geographical regions.

RNA-binding properties of a translational activator, the adenovirus L4 100-kilodalton protein.

Human foamy virus polypeptides: identification of env and bel gene products.

Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin.

A second nonstructural protein functions in the regulation of alphavirus negative-strand RNA synthesis.

Subgenomic RNA sequence of human astrovirus supports classification of Astroviridae as a new family of RNA viruses.

Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein.

Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect.

Inhibition of retrovirus-induced disease in mice by camptothecin.

Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria.

Transforming variants of the avian myc-containing retrovirus FH3 arise prior to phenotypic selection.

Association of human immunodeficiency virus type 1 envelope glycoprotein with particles depends on interactions between the third variable and conserved regions of gp120.

An immortalized human fibroblast cell line is permissive for human cytomegalovirus infection.

A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism.

The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.

A monoclonal antibody to the CDR-3 region of CD4 inhibits soluble CD4 binding to virions of human immunodeficiency virus type 1.

The cowpea mosaic virus M RNA-encoded 48-kilodalton protein is responsible for induction of tubular structures in protoplasts.

Increased hematopoiesis in mice soon after infection by Friend murine leukemia virus.

Simian virus 40 small-t antigen binds two zinc ions.

Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody.

Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus.

Complementation of a poliovirus defective genome by a recombinant vaccinia virus which provides poliovirus P1 capsid precursor in trans.

A three-nucleotide insertion in the H stem-loop of the 5' untranslated region of Theiler's virus attenuates neurovirulence.

Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen.

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Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes.

Content Provider	PubMed Central
Author	Zhou, C. Hao, Q. L. Guatelli, J. C. Kohn, D. B. Bahner, I. Yu, X. J.
Abstract	trans-Dominant inhibitory mutant versions of the human immunodeficiency virus type 1 (HIV-1) regulatory genes tat and rev have previously been described. We have constructed a series of retroviral vectors to transduce these genes and compare their inhibitory activities. The inhibitory activities were measured with transient transfection assays by using a reporter which expresses an HIV-1 gag-Escherichia coli lacZ fusion protein with strict dependence on coexpression of both tat and rev. Additionally, the vectors were packaged as amphotropic virions and used to stably transduce human CEM T lymphocytes. The transduced CEM cells were challenged with HIV-1, and the effects of the mutant HIV-1 genes were determined by measuring the levels of HIV-1 p24gag produced. A tat gene substituted at amino acid 41 (tatk41a) retained partial trans-activating activity and lacked inhibitory activity. A tat gene with a premature stop codon at amino acid 54 (tat54ter) showed moderate trans-dominant inhibition of the reporter plasmid but failed to significantly inhibit HIV-1 replication. The M10 rev mutant, with a 2-amino-acid substitution, showed strong trans-dominant inhibitory activity both in the reporter plasmid and in the HIV-1 infection assay. The greatest inhibition of HIV-1 growth was seen when M10 was expressed under the transcriptional control of a human cytomegalovirus promoter; slightly less inhibition was achieved when expression of M10 was controlled by the Moloney murine leukemia virus long terminal repeat, and minimal inhibition was seen when the HIV-1 long terminal repeat controlled the M10 gene. These results demonstrate the potential utility of retroviral vectors expressing trans-dominant inhibitory mutant HIV-1 genes for gene therapy approaches to AIDS.
Starting Page	3199
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	6
Volume Number	67
Language	English
Publisher Date	1993-06-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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