NDLI: Sequence requirements of the Epstein-Barr virus latent origin of DNA replication.

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Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways.

Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia.

Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo.

Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomas.

A monoclonal antibody that blocks poliovirus attachment recognizes the lymphocyte homing receptor CD44.

Alterations of the p53 gene in Epstein-Barr virus-associated immunodeficiency-related lymphomas.

Nucleocapsid-glycoprotein interactions required for assembly of alphaviruses.

The presence of tat protein or tumor necrosis factor alpha is critical for herpes simplex virus type 1-induced expression of human immunodeficiency virus type 1.

The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.

Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated.

Phosphorylation of varicella-zoster virus open reading frame (ORF) 62 regulatory product by viral ORF 47-associated protein kinase.

Targeting of a multicomponent transcription apparatus into assembling vaccinia virus particles requires RAP94, an RNA polymerase-associated protein.

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Sequence and genome organization of Borna disease virus.

Use of an autonomous parvovirus vector for selective transfer of a foreign gene into transformed human cells of different tissue origins and its expression therein.

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Antibody and cytotoxic T-cell responses to soluble hepatitis B virus (HBV) S antigen in mice: implication for the pathogenesis of HBV-induced hepatitis.

Giardiavirus-resistant Giardia lamblia lacks a virus receptor on the cell membrane surface.

Influenza virus NS1 protein stimulates translation of the M1 protein.

Inhibition of murine AIDS (MAIDS), development by the transplantation of bone marrow cells carrying the Fv-4 resistance gene to MAIDS virus-infected mice.

Down-regulation of HLA antigens by the adenovirus type 2 E3/19K protein in a T-lymphoma cell line.

An Epstein-Barr virus with a 58-kilobase-pair deletion that includes BARF0 transforms B lymphocytes in vitro.

Activities of the feline immunodeficiency virus integrase protein produced in Escherichia coli.

Subcellular distribution of human immunodeficiency virus type 1 Rev and colocalization of Rev with RNA splicing factors in a speckled pattern in the nucleoplasm.

Antigenic determinants of measles virus hemagglutinin associated with neurovirulence.

Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses.

Translational frameshifting at the gag-pol junction of human immunodeficiency virus type 1 is not increased in infected T-lymphoid cells.

Recombinant influenza virus polymerase: requirement of both 5' and 3' viral ends for endonuclease activity.

Spontaneous development of anti-hepatitis B virus envelope (anti-idiotypic) antibodies in animals immunized with human liver endonexin II or with the F(ab')2 fragment of anti-human liver endonexin II immunoglobulin G: evidence for a receptor-ligand-like relationship between small hepatitis B surface antigen and endonexin II.

Functional analysis of N-linked glycosylation mutants of the measles virus fusion protein synthesized by recombinant vaccinia virus vectors.

Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.

Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro.

Influenza A virus M2 ion channel protein: a structure-function analysis.

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Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus.

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Genomic cloning and complete sequence analysis of a highly divergent African human immunodeficiency virus isolate.

Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers.

Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.

Hormonal regulation of the gene for the type C ecotropic retrovirus receptor in rat liver cells.

Mucosal model of genital immunization in male rhesus macaques with a recombinant simian immunodeficiency virus p27 antigen.

Genetic analysis of the human immunodeficiency virus type 1 integrase protein.

Mapping a region of the large envelope protein required for hepatitis B virion maturation.

Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis.

Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy.

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Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation.

Rearrangement of the VP6 gene of a group A rotavirus in combination with a point mutation affecting trimer stability.

Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein.

A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.

Identification and characterization of a human herpesvirus 6 gene segment capable of transactivating the human immunodeficiency virus type 1 long terminal repeat in an Sp1 binding site-dependent manner.

Cysteine residues in the Vif protein of human immunodeficiency virus type 1 are essential for viral infectivity.

Comparison of the effects of Sindbis virus and Sindbis virus replicons on host cell protein synthesis and cytopathogenicity in BHK cells.

Identification and characterization of a protein kinase gene in the Lymantria dispar multinucleocapsid nuclear polyhedrosis virus.

Multigenic evasion of inflammation by poxviruses.

An 85-kilodalton herpes simplex virus type 1 alpha trans-induction factor (VP16)-VP13/14 fusion protein retains the transactivation and structural properties of the wild-type molecule during virus infection.

Repression of enhancer II activity by a negative regulatory element in the hepatitis B virus genome.

Killer toxin-secreting double-stranded RNA mycoviruses in the yeasts Hanseniaspora uvarum and Zygosaccharomyces bailii.

Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein.

Viral multiplicity of attachment and its implications for human immunodeficiency virus therapies.

Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase.

Splice site selection in polyomavirus late pre-mRNA processing.

Down-regulation of major histocompatibility complex class I synthesis by murine cytomegalovirus early gene expression.

Analysis of the signals for polarized transport of influenza virus (A/WSN/33) neuraminidase and human transferrin receptor, type II transmembrane proteins.

Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1.

RAZ, an Epstein-Barr virus transdominant repressor that modulates the viral reactivation mechanism.

Role of oligomerization of the S13 Env-Sea oncoprotein in cell transformation.

Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines.

Induction of HLA class I and class II expression in human T-lymphotropic virus type I-infected neuroblastoma cells.

Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain.

Regulation of Sindbis virus RNA replication: uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesis.

Molecular evolution of herpesviruses: genomic and protein sequence comparisons.

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Sequence requirements of the Epstein-Barr virus latent origin of DNA replication.

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Structure of intracellular mature vaccinia virus observed by cryoelectron microscopy.

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon.

Photoinactivation and kinetics of membrane fusion mediated by the human immunodeficiency virus type 1 envelope glycoprotein.

The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells.

Redesignation of the RNase D activity associated with retroviral reverse transcriptase as RNase H.

The activity of the pseudorabies virus latency-associated transcript promoter is dependent on its genomic location in herpes simplex virus recombinants as well as on the type of cell infected.

gp120-independent fusion mediated by the human immunodeficiency virus type 1 gp41 envelope glycoprotein: a reassessment.

Varicella-zoster virus open reading frame 4 protein is functionally distinct from and does not complement its herpes simplex virus type 1 homolog, ICP27.

Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus.

Functional role of the zipper motif region of human immunodeficiency virus type 1 transmembrane protein gp41.

Intermediates of adeno-associated virus DNA replication in vitro.

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor.

Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal.

Woodchuck hepatitis virus X protein is required for viral infection in vivo.

Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene.

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Sequence requirements of the Epstein-Barr virus latent origin of DNA replication.

Content Provider	PubMed Central
Author	Harrison, S. Fisenne, K. Hearing, J.
Abstract	The Epstein-Barr virus (EBV) latent origin of DNA replication (oriP) is composed of two elements that contain binding sites for the sole viral gene product required for latent cycle replication, EBNA-1. One of these elements, region I, functions as an EBNA-1-dependent enhancer for RNA polymerase II-transcribed genes, may play a role in plasmid segregation, and is required for origin function in B cells latently infected with EBV. The second element, region II, contains or is very near the site of initiation of DNA replication. A genetic approach was taken to determine the contribution of the EBNA-1 binding sites in oriP to origin function. Although region I is required for the transient replication of plasmids bearing region II in EBV-infected B cells, a plasmid lacking region I but containing region II, was observed to replicate transiently in both D98/Raji and HeLa cells expressing EBNA-1. Thus, binding of EBNA-1 to region I is not absolutely required for the molecular events that lead to initiation of DNA replication at region II. Site-directed mutagenesis of the four EBNA-1-binding sites in region II, individually and in various combinations, demonstrated that only two EBNA-1-binding sites are required for region II function. The results obtained with these mutants, together with the analysis of the replicative ability of plasmids containing insertions between EBNA-1-binding sites, suggested that the spatial relationship of the two sites is critical. Mutants that contain only two EBNA-1-binding sites separated by 26 to 31 bp in region II were not maintained as plasmids over many cell generations and were greatly reduced in their ability to replicate transiently in D98/Raji cells. The EBNA-1-induced bending or untwisting of the DNA in EBNA-1-binding sites 1 and 4 in region II did not, however, demonstrate this spatial constraint. It may be concluded from these results that specific protein-protein interactions between EBNA-1 and/or between EBNA-1 and a cellular protein(s) are required for origin function.
Starting Page	1913
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	3
Volume Number	68
Language	English
Publisher Date	1994-03-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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