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| Content Provider | PubMed Central |
|---|---|
| Author | Robinson, Jennifer G. |
| Copyright Year | 2008 |
| Abstract | Trials of peroxisome proliferator-activated receptor (PPAR) agonists have shown mixed results for cardiovascular prevention. Fibrates are PPAR- α agonists that act primarily to improve dyslipidemia. Based on low- and high-density lipoprotein cholesterol (LDL and HDL) effects, gemfibrozil may be of greater cardiovascular benefit than expected, fenofibrate performed about as expected, and bezafibrate performed worse than expected. Increases in both cardiovascular and noncardiovascular serious adverse events have been observed with some fibrates. Thiazolidinediones (TZDs) are PPAR- γ agonists used to improve impaired glucose metabolism but also influence lipids. Pioglitazone reduces atherosclerotic events in diabetic subjects, but has no net cardiovascular benefit due to increased congestive heart failure risk. Rosiglitazone may increase the risk of atherosclerotic events, and has a net harmful effect on the cardiovascular system when congestive heart failure is included. The primary benefit of TZDs appears to be the prevention of diabetic microvascular complications. Dual PPAR- α / γ agonists have had unacceptable adverse effects but more selective agents are in development. PPAR- δ and pan-agonists are also in development. It will be imperative to prove that future PPAR agonists not only prevent atherosclerotic events but also result in a net reduction on total cardiovascular events without significant noncardiovascular adverse effects with long-term use. |
| Related Links | http://dx.doi.org/10.1155/2008/891425 |
| Starting Page | 891425 |
| File Format | |
| ISSN | 16874757 |
| e-ISSN | 16874765 |
| Journal | PPAR Research |
| Volume Number | 2008 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Pharmacology (medical) Drug Discovery Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology (medical) |
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