NDLI: Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell

Content Provider	PubMed Central
Author	Dunn, Shannon E. Ousman, Shalina S. Sobel, Raymond A. Zuniga, Luis Baranzini, Sergio E. Youssef, Sawsan Crowell, Andrea Loh, John Oksenberg, Jorge Steinman, Lawrence
Abstract	Peroxisome proliferator–activated receptor (PPAR)α is a nuclear receptor that mediates gender differences in lipid metabolism. PPARα also functions to control inflammatory responses by repressing the activity of nuclear factor κB (NF-κB) and c-jun in immune cells. Because PPARα is situated at the crossroads of gender and immune regulation, we hypothesized that this gene may mediate sex differences in the development of T cell–mediated autoimmune disease. We show that PPARα is more abundant in male as compared with female CD4+ cells and that its expression is sensitive to androgen levels. Genetic ablation of this gene selectively removed the brake on NF-κB and c-jun activity in male T lymphocytes, resulting in higher production of interferon γ and tumor necrosis factor (but not interleukin 17), and lower production of T helper (Th)2 cytokines. Upon induction of experimental autoimmune encephalomyelitis, male but not female PPARα−/− mice developed more severe clinical signs that were restricted to the acute phase of disease. These results suggest that males are less prone to develop Th1-mediated autoimmunity because they have higher T cell expression of PPARα.
Related Links	http://dx.doi.org/10.1084/jem.20061839
Ending Page	330
Page Count	10
Starting Page	321
File Format	PDF
ISSN	00221007
e-ISSN	15409538
Journal	The Journal of Experimental Medicine
Issue Number	2
Volume Number	204
Language	English
Publisher	The Rockefeller University Press
Publisher Date	2007-02-19
Access Restriction	Open
Rights Holder	The Rockefeller University Press
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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