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| Content Provider | PubMed Central |
|---|---|
| Author | Dan, Mishmar Ayelet, Rahat Scherer, Stephen W. Gerald, Nyakatura Hinzmann, Bernd Kohwi, Yoshinori Yael, Mandel-gutfroind Lee, Jeffrey R. Drescher, Bernd Sas, Dean E. Margalit, Hanah Platzer, Mattias Weiss, Aryeh Tsui, Lap-chee Rosenthal, André Kerem, Batsheva |
| Copyright Year | 1998 |
| Abstract | Common fragile sites are chromosomal loci prone to breakage and rearrangement, hypothesized to provide targets for foreign DNA integration. We cloned a simian virus 40 integration site and showed by fluorescent in situ hybridization analysis that the integration event had occurred within a common aphidicolin-induced fragile site on human chromosome 7, FRA7H. A region of 161 kb spanning FRA7H was defined and sequenced. Several regions with a potential unusual DNA structure, including high-flexibility, low-stability, and non-B-DNA-forming sequences were identified in this region. We performed a similar analysis on the published FRA3B sequence and the putative partial FRA7G, which also revealed an impressive cluster of regions with high flexibility and low stability. Thus, these unusual DNA characteristics are possibly intrinsic properties of common fragile sites that may affect their replication and condensation as well as organization, and may lead to fragility. |
| Starting Page | 8141 |
| File Format | |
| ISSN | 10916490 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 95 |
| Language | English |
| Publisher | The National Academy of Sciences |
| Publisher Date | 1998-07-07 |
| Access Restriction | Open |
| Rights Holder | The National Academy of Sciences |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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