NDLI: Charge transport and intrinsic fluorescence in amyloid-like fibrils

Content Provider	PubMed Central
Author	Del, Mercato Loretta Laureana Pompa, Pier Paolo Giuseppe, Maruccio Torre, Antonio Della Sabella, Stefania Tamburro, Antonio Mario Cingolani, Roberto Rinaldi, Ross
Copyright Year	2007
Abstract	The self-assembly of polypeptides into stable, conductive, and intrinsically fluorescent biomolecular nanowires is reported. We have studied the morphology and electrical conduction of fibrils made of an elastin-related polypeptide, poly(ValGlyGlyLeuGly). These amyloid-like nanofibrils, with a diameter ranging from 20 to 250 nm, result from self-assembly in aqueous solution at neutral pH. Their morphological properties and conductivity have been investigated by atomic force microscopy, scanning tunneling microscopy, and two-terminal transport experiments at the micro- and nanoscales. We demonstrate that the nanofibrils can sustain significant electrical conduction in the solid state at ambient conditions and have remarkable stability. We also show intrinsic blue-green fluorescence of the nanofibrils by confocal microscopy analyses. These results indicate that direct (label-free) excitation can be used to investigate the aggregation state or the polymorphism of amyloid-like fibrils (and possibly of other proteinaceous material) and open up interesting perspectives for the use of peptide-based nanowire structures, with tunable physical and chemical properties, for a wide range of nanobiotechnological and bioelectronic applications.
Related Links	http://dx.doi.org/10.1073/pnas.0702843104
Ending Page	18024
Page Count	6
Starting Page	18019
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	46
Volume Number	104
Language	English
Publisher	National Academy of Sciences
Publisher Date	2007-11-13
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Correction for del Mercato et al., Charge transport and intrinsic fluorescence in amyloid-like fibrils

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Correction for del Mercato et al., Charge transport and intrinsic fluorescence in amyloid-like fibrils

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